1.02011-09-21 00:04:36 UTC2015-10-09 22:29:17 UTCFDB021888CortisolCortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.; As an oral or injectable drug, cortisol is also known as hydrocortisone. It is used as an immunosuppressive drug, given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients who need steroid treatment but cannot take oral medication, and peri-operatively in patients on long-term steroid treatment to prevent an Addisonian crisis.; Cortisol or Hydrocortisone is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress. It increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Its synthetic counterpart (hydrocortisone) is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Cortisol is synthesized from pregnenolone. The amount of cortisol present in the serum undergoes diurnal variation, with the highest levels present in the early morning, and lower levels in the evening, several hours after the onset of sleep.; Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation. [HMDB]11-beta-Hydrocortisone11-beta-Hydroxycortisone11-Hydrocortisone11a-Hydroxycorticosterone11alpha-Hydroxycorticosterone11b-Hydrocortisone11b-Hydroxycortisone11b,17,21-Trihydroxyprogesterone11beta-Hydrocortisone11beta-Hydroxycortisone11beta,17,21-Trihydroxyprogesterone17-Hydroxycorticosterone17a-Hydroxycorticosterone17alpha-Hydroxycorticosterone4-Pregnene-11alpha,21-triol 3,20-dione4-Pregnene-11b,17a,21-triol-3,20-dioneActicortAeroseb HCAeroseb-HCAla-CortAla-ScalpAlacortAlgicirtisalphadermAmberinAnflamAnti-inflammatory hormoneAquacortAquanil HCBarseb HCBasan-CortiCaldeCORT SprayCetacortChronocortClear aidCleitonCobadexCompound FCor-Tar-QuinCort-DomeCort-QuinCortanalCortenemaCortesalCorticremeCortifanCortifoamCortimentCortisol alcoholCortisolonumCortisporinCortisporin OticoCortisprayCortizolCortolotionCortonemaCortoxideCremesoneCremicort-HCutisolDelacortDerm-AidDermilDermolateDihydrocostisoneDiodermDome-cortDomolene-HCDroticEf corlinEfcorbinEfcortelanEfcortelinEldercortEpicortEpiderm HEsiderm HEvacortFicortrilFiocortrilFoille InsettiGenacortGyno-CortisoneH-CortHCHeb CortHeb-CortHidaloneHidro-ColisonaHidrocortisonaHycortHycortolHycortoleHydracortHydrassonHydro-AdresonHydro-colisonaHydrocortHydrocortalHydrocorticosteroneHydrocortisoneHydrocortisone alcoholHydrocortisone baseHydrocortisone free alcoholHydrocortisonumHydrocortistabHydrocortisylHydrocortoneHydroskinHydroxycortisoneHysoneHytisoneHytoneHytone lotionIdrocortisoneIncortin-HIncortin-hydrogenKendall's compound FKomed HCKyypakkausLacticare HCLacticare-HCLactisonaLubricortMaintasoneMedicortMeusicortMildisonMillidermNeo-Cort-DomeNeosporin-H EarNutracortNystaform-HCOptefOtalgineOtic-Neo-Cort-DomeOtobioticOtocortOtosone-FPediotic SuspensionPenecortPermicortPolcort HPreparation H Hydrocortisone CreamPrepcortPrestwick_265Prevex HCProctocortProctofoamProtocortRacetRectoidReichstein's substance MRemederm HCSanatisonScalpicin CapilarSchericurScheroson FSigmacortSignefStiefcorcilSynacortSystral HydrocortTarcortinTimocortTopicortTransderma HTraumaideUnidermVioform-HydrocortisoneVoSol HCVytoneZenoxoneC21H30O5362.4599362.20932407(1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one(1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one50-23-7[H][C@@]12CC[C@@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12CInChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21+/m0/s1JYGXADMDTFJGBT-CZFMHFDVSA-N belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.21-hydroxysteroidsOrganic compoundsLipids and lipid-like moleculesSteroids and steroid derivativesHydroxysteroidsAliphatic homopolycyclic compounds11-beta-hydroxysteroids17-hydroxysteroids20-oxosteroids3-oxo delta-4-steroidsAlpha-hydroxy ketonesCyclic alcohols and derivativesCyclohexenonesDelta-4-steroidsGluco/mineralocorticoids, progestogins and derivativesHydrocarbon derivativesOrganic oxidesPrimary alcoholsSecondary alcoholsTertiary alcohols11-beta-hydroxysteroid11-hydroxysteroid17-hydroxysteroid20-oxosteroid21-hydroxysteroid3-oxo-delta-4-steroid3-oxosteroidAlcoholAliphatic homopolycyclic compoundAlpha-hydroxy ketoneCarbonyl groupCyclic alcoholCyclic ketoneCyclohexenoneDelta-4-steroidHydrocarbon derivativeKetoneOrganic oxideOrganic oxygen compoundOrganooxygen compoundOxosteroidPregnane-skeletonPrimary alcoholProgestogin-skeletonSecondary alcoholTertiary alcoholSolidlogp1.79logs-3.26solubility1.99e-01 g/llogp1.28pka_strongest_acidic12.58pka_strongest_basic-2.8iupac(1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-oneaverage_mass362.4599mono_mass362.20932407smiles[H][C@@]12CC[C@@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12CformulaC21H30O5inchiInChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21+/m0/s1inchikeyJYGXADMDTFJGBT-CZFMHFDVSA-Npolar_surface_area94.83refractivity97.4polarizability39.63rotatable_bond_count2acceptor_count5donor_count3physiological_charge0formal_charge0SteroidogenesisSMP00130map00140Specdb::CMs11575Specdb::CMs37275Specdb::MsMs291532Specdb::MsMs291533Specdb::MsMs291534Specdb::MsMs331471Specdb::MsMs331472Specdb::MsMs331473HMDB00063#<Reference:0x0000555674f320f8>#<Reference:0x0000555674f31f18>#<Reference:0x0000555674f31d60>#<Reference:0x0000555674f31ae0>#<Reference:0x0000555674f318d8>#<Reference:0x0000555674f314a0>#<Reference:0x0000555674f31068>#<Reference:0x0000555674f30b68>#<Reference:0x0000555674f308e8>#<Reference:0x0000555674f305c8>#<Reference:0x0000555674f3ba18>#<Reference:0x0000555674f3b798>#<Reference:0x0000555674f3b0b8>#<Reference:0x0000555674f3af00>#<Reference:0x0000555674f3ad20>#<Reference:0x0000555674f3aaf0>#<Reference:0x0000555674f3a938>#<Reference:0x0000555674f3a780>#<Reference:0x0000555674f3a3e8>#<Reference:0x0000555674f3a1e0>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823bitterCorticosteroid 11-beta-dehydrogenase isozyme 1P28845HSD11B1Cytochrome P450 21-hydroxylaseQ16874P450-CYP21BCytochrome P450, family 21, subfamily A, polypeptide 2Q08AG9CYP21A2