1.02011-09-21 00:07:20 UTC2015-07-21 06:56:56 UTCFDB02203318-Hydroxycortisol18-Hydroxycortisol is a derivative of cortIsolated It may be synthesized by zona fasciculata 11-beta hydroxylase in normal human adrenal cortex. (PMID 15356073; 1751390) Overproduction of 18-hydroxycortisol is an aid in the detection of Glucocorticoid-remediable aldosteronism which is an inherited form of mineralocorticoid excess associated with moderate overproduction of aldosterone, in which biochemical and clinical remission is dramatically induced by small amounts of glucocorticoids.(PMID: 1879399) [HMDB]11,17,18,21-tetrahydroxy-pregn-4-ene-3,20-dione18-HydroxycortisolC21H30O6378.4593378.204238692(1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-15-(hydroxymethyl)-2-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one18-hydroxycortisol86002-90-6[H][C@@]12CC[C@@](O)(C(=O)CO)[C@@]1(CO)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12CInChI=1S/C21H30O6/c1-19-6-4-13(24)8-12(19)2-3-14-15-5-7-21(27,17(26)10-22)20(15,11-23)9-16(25)18(14)19/h8,14-16,18,22-23,25,27H,2-7,9-11H2,1H3/t14-,15-,16-,18+,19-,20+,21+/m0/s1HESFZGWRDUVOMS-FJNAKSJRSA-N belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.21-hydroxysteroidsOrganic compoundsLipids and lipid-like moleculesSteroids and steroid derivativesHydroxysteroidsAliphatic homopolycyclic compounds11-beta-hydroxysteroids17-hydroxysteroids18-hydroxysteroids20-oxosteroids3-oxo delta-4-steroidsAlpha-hydroxy ketonesCyclic alcohols and derivativesCyclohexenonesDelta-4-steroidsGluco/mineralocorticoids, progestogins and derivativesHydrocarbon derivativesOrganic oxidesPrimary alcoholsSecondary alcoholsTertiary alcohols11-beta-hydroxysteroid11-hydroxysteroid17-hydroxysteroid18-hydroxysteroid20-oxosteroid21-hydroxysteroid3-oxo-delta-4-steroid3-oxosteroidAlcoholAliphatic homopolycyclic compoundAlpha-hydroxy ketoneCarbonyl groupCyclic alcoholCyclic ketoneCyclohexenoneDelta-4-steroidHydrocarbon derivativeKetoneOrganic oxideOrganic oxygen compoundOrganooxygen compoundOxosteroidPregnane-skeletonPrimary alcoholProgestogin-skeletonSecondary alcoholTertiary alcoholC21 steroids (gluco/mineralocorticoids, progestogins) and derivativesSolidlogp0.65logs-2.45solubility1.34e+00 g/llogp-0.0056pka_strongest_acidic12.51pka_strongest_basic-2.8iupac(1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-15-(hydroxymethyl)-2-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-oneaverage_mass378.4593mono_mass378.204238692smiles[H][C@@]12CC[C@@](O)(C(=O)CO)[C@@]1(CO)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12CformulaC21H30O6inchiInChI=1S/C21H30O6/c1-19-6-4-13(24)8-12(19)2-3-14-15-5-7-21(27,17(26)10-22)20(15,11-23)9-16(25)18(14)19/h8,14-16,18,22-23,25,27H,2-7,9-11H2,1H3/t14-,15-,16-,18+,19-,20+,21+/m0/s1inchikeyHESFZGWRDUVOMS-FJNAKSJRSA-Npolar_surface_area115.06refractivity99.17polarizability40.12rotatable_bond_count3acceptor_count6donor_count4physiological_charge0formal_charge0Specdb::NmrOneD143790Specdb::NmrOneD143791Specdb::NmrOneD143792Specdb::NmrOneD143793Specdb::NmrOneD143794Specdb::NmrOneD143795Specdb::NmrOneD143796Specdb::NmrOneD143797Specdb::NmrOneD143798Specdb::NmrOneD143799Specdb::NmrOneD143800Specdb::NmrOneD143801Specdb::NmrOneD143802Specdb::NmrOneD143803Specdb::NmrOneD143804Specdb::NmrOneD143805Specdb::NmrOneD143806Specdb::NmrOneD143807Specdb::NmrOneD143808Specdb::NmrOneD143809Specdb::CMs18192Specdb::CMs37518Specdb::CMs167464Specdb::CMs1061044Specdb::CMs1061046Specdb::CMs1061048Specdb::CMs1061050Specdb::CMs1061052Specdb::CMs1061054Specdb::CMs1061056Specdb::CMs1061058Specdb::CMs1061060Specdb::CMs1061063Specdb::CMs1061064Specdb::CMs1061066Specdb::CMs1061068Specdb::CMs1061070Specdb::CMs1061072Specdb::CMs1061074Specdb::CMs1061076Specdb::CMs1061078Specdb::CMs1061080Specdb::CMs1061083Specdb::CMs1061085Specdb::CMs1061087Specdb::MsMs143961Specdb::MsMs143962Specdb::MsMs143963Specdb::MsMs2687801Specdb::MsMs2687802Specdb::MsMs2687803Specdb::MsMs42801Specdb::MsMs42802Specdb::MsMs42803Specdb::MsMs2994248Specdb::MsMs2994249Specdb::MsMs2994250HMDB00418#<Reference:0x00005556740016b0>#<Reference:0x00005556740013e0>#<Reference:0x0000555674001138>#<Reference:0x0000555674000eb8>#<Reference:0x0000555674000d00>#<Reference:0x0000555674000b48>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823