1.02011-09-21 00:29:10 UTC2015-07-21 06:57:41 UTCFDB023387O-DesmethylangolensinO-Desmethylangolensin (ODMA) is a metabolite of the soy isoflavone daidzein by intestinal bacteria in approximately 80-90% of persons. Studies suggest beneficial health effects associated with daidzein-metabolizing phenotypes, and there is some small association between ODMA production and some phenotypes. Few dietary factors are associated with daidzein-metabolizing phenotypes. However, it remains unclear why some, but not all, persons harbor ODMA-producing bacteria. ODMA production is inversely associated with age, height, weight, and body mass index. In addition, Asians are less likely than whites to be ODMA producers, and former smokers were more likely than never smokers to be ODMA producers. Investigators have attempted to identify the bacteria involved in ODMA production, and several candidate bacteria were associated, but not definitely identified. ODMA production is correlated with the abundance of methanogens, indicating that the metabolic fate of daidzein may be related to intestinal H(2) metabolism. (PMID: 18326607, 17506823) [HMDB]2,4-Dihydroxyphenyl p-hydroxyphenethyl ketone2',4'-dihydroxy-2-(p-hydroxyphenyl)-PropiophenoneO-DemethylangolensinO-DemethylangolesinC15H14O4258.2693258.0892089361-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propan-1-oneO-desmethylangolensin21255-69-6CC(C(=O)C1=C(O)C=C(O)C=C1)C1=CC=C(O)C=C1InChI=1S/C15H14O4/c1-9(10-2-4-11(16)5-3-10)15(19)13-7-6-12(17)8-14(13)18/h2-9,16-18H,1H3JDJPNKPFDDUBFV-UHFFFAOYSA-N belongs to the class of organic compounds known as alpha-methyldeoxybenzoin flavonoids. These are flavonoids with a structure based on a 1,2-diphenyl-2-propan-2-one.Alpha-methyldeoxybenzoin flavonoidsOrganic compoundsPhenylpropanoids and polyketidesAlpha-methyldeoxybenzoin flavonoidsAromatic homomonocyclic compounds1-hydroxy-2-unsubstituted benzenoids1-hydroxy-4-unsubstituted benzenoidsAlkyl-phenylketonesAryl alkyl ketonesBenzoyl derivativesHydrocarbon derivativesOrganic oxidesPhenylpropanesResorcinolsStilbenesVinylogous acids1-hydroxy-2-unsubstituted benzenoid1-hydroxy-4-unsubstituted benzenoidAlkyl-phenylketoneAlpha-methyldeoxybenzoin flavonoidAromatic homomonocyclic compoundAryl alkyl ketoneAryl ketoneBenzenoidBenzoylHydrocarbon derivativeKetoneMonocyclic benzene moietyOrganic oxideOrganic oxygen compoundOrganooxygen compoundPhenolPhenylketonePhenylpropaneResorcinolStilbeneVinylogous acidSolidlogp2.98logs-3.49solubility8.39e-02 g/llogp3.65pka_strongest_acidic7.83pka_strongest_basic-4.9iupac1-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propan-1-oneaverage_mass258.2693mono_mass258.089208936smilesCC(C(=O)C1=C(O)C=C(O)C=C1)C1=CC=C(O)C=C1formulaC15H14O4inchiInChI=1S/C15H14O4/c1-9(10-2-4-11(16)5-3-10)15(19)13-7-6-12(17)8-14(13)18/h2-9,16-18H,1H3inchikeyJDJPNKPFDDUBFV-UHFFFAOYSA-Npolar_surface_area77.76refractivity71.7polarizability26.38rotatable_bond_count3acceptor_count4donor_count3physiological_charge0formal_charge0Specdb::CMs18683Specdb::CMs38774Specdb::CMs132368Specdb::CMs140102Specdb::MsMs53490Specdb::MsMs53491Specdb::MsMs53492Specdb::MsMs120639Specdb::MsMs120640Specdb::MsMs120641Specdb::MsMs2759318Specdb::MsMs2759319Specdb::MsMs2759320Specdb::MsMs2949828Specdb::MsMs2949829Specdb::MsMs2949830HMDB04629#<Reference:0x00005556741499a0>#<Reference:0x00005556741497e8>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823