Showing Compound Vanillic acid (FDB000846)

Record Information

Version

1.0

Creation date

2010-04-08 22:04:44 UTC

Update date

2019-11-26 02:55:31 UTC

Primary ID

FDB000846

Secondary Accession Numbers

Not Available

Chemical Information

FooDB Name

Vanillic acid

Description

Vanillic acid is a phenolic acid found in some forms of vanilla and many other plant extracts. It is a flavoring and scent agent that produces a pleasant, creamy odor. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13). Vanillic acid, which is a chlorogenic acid, is an oxidized form of vanillin. It is also an intermediate in the production of vanillin from ferulic acid. Vanillic acid is a metabolic byproduct of caffeic acid and is often found in the urine of humans who have consumed coffee, chocolate, tea and vanilla-flavored confectionary. Vanillic acid selectively and specifically inhibits 5'nucleotidase activity. (PMID: 16899266).

CAS Number

121-34-6

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Synonym	Source
4-Hydroxy-3-methoxybenzoic acid	ChEBI
4-Hydroxy-3-methoxybenzoate	Kegg
Vanillate	Generator
3-Methoxy-4-hydroxybenzoate	HMDB
3-Methoxy-4-hydroxybenzoic acid	HMDB
4-Hydroxy-3-methoxy-benzoate	HMDB
4-Hydroxy-3-methoxy-benzoic acid	HMDB
4-Hydroxy-m-anisate	HMDB
4-Hydroxy-m-anisic acid	HMDB
Acide vanillique	HMDB
p-Vanillate	HMDB
p-Vanillic acid	HMDB
Protocatechuic acid 3-methyl ester	HMDB
Acid, 4-hydroxy-3-methoxybenzoic	HMDB
p Hydroxy m methoxy benzoic acid	HMDB
4 Hydroxy 3 methoxybenzoic acid	HMDB
Acid, vanillic	HMDB
Acid, p-hydroxy-m-methoxy-benzoic	HMDB
p-Hydroxy-m-methoxy-benzoic acid	HMDB
2-Methoxy-4-carboxyphenol	HMDB
Methylprotocatechuic acid	HMDB
VA	HMDB
m-Methoxy-p-hydroxy-benzoic acid	HMDB
Vanillic acid	KEGG
4 Hydroxy 3 methoxybenzoic Acid	biospider
4-hydroxy-3-methoxy-Benzoate	biospider
4-hydroxy-3-methoxy-Benzoic acid	biospider
4-Hydroxy-3-methoxybenzoic acid (vanillic acid)	biospider
4-hydroxy-m-Anisate	biospider
4-hydroxy-m-Anisic acid	biospider
Acid, 4-Hydroxy-3-methoxybenzoic	biospider
Benzoic acid, 4-hydroxy-3-methoxy-	biospider
m-Anisic acid, 4-hydroxy-	biospider
P hydroxy m methoxy benzoic acid	biospider
P-hydroxy-m-methoxy-benzoic acid	biospider
P-hydroxy-m-methoxy-benzonic acid	biospider
P-vanillate	biospider
P-vanillic acid	biospider
Protocatechuic acid, 3-methyl ester	biospider
Va (van)	biospider
VNL	biospider

Predicted Properties

Property	Value	Source
Water Solubility	5.7 g/L	ALOGPS
logP	1.7	ALOGPS
logP	1.17	ChemAxon
logS	-1.5	ALOGPS
pKa (Strongest Acidic)	4.16	ChemAxon
pKa (Strongest Basic)	-4.9	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	66.76 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	41.76 m³·mol⁻¹	ChemAxon
Polarizability	15.86 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Chemical Formula

C8H8O4

IUPAC name

4-hydroxy-3-methoxybenzoic acid

InChI Identifier

InChI=1S/C8H8O4/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4,9H,1H3,(H,10,11)

InChI Key

WKOLLVMJNQIZCI-UHFFFAOYSA-N

Isomeric SMILES

COC1=C(O)C=CC(=C1)C(O)=O

Average Molecular Weight

168.148

Monoisotopic Molecular Weight

168.042258738

Classification

Description

Belongs to the class of organic compounds known as m-methoxybenzoic acids and derivatives. These are benzoic acids in which the hydrogen atom at position 3 of the benzene ring is replaced by a methoxy group.

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Benzene and substituted derivatives

Sub Class

Benzoic acids and derivatives

Direct Parent

M-methoxybenzoic acids and derivatives

Alternative Parents

Substituents

M-methoxybenzoic acid or derivatives
Hydroxybenzoic acid
Methoxyphenol
Benzoic acid
Anisole
Phenoxy compound
Benzoyl
Phenol ether
Methoxybenzene
1-hydroxy-2-unsubstituted benzenoid
Alkyl aryl ether
Phenol
Monocarboxylic acid or derivatives
Ether
Carboxylic acid
Carboxylic acid derivative
Organic oxide
Organic oxygen compound
Organooxygen compound
Hydrocarbon derivative
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

monohydroxybenzoic acid (CHEBI:30816 )
methoxybenzoic acid (CHEBI:30816 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Food

Biological:

Plant:

Microbe:

Amycolatopsis

Pseudomonas:

Delftia:

Delftia acidivorans

Biological location:

Subcellular:

Cytoplasm

Biofluid and excreta:

Foods

Cocoa and cocoa products

Grains:

Cereal products:

Whole grain cereal products

Nuts and legumes:

Fruits and vegetables:

Fats and oils:

Oils:

Vegetable oils:

Olive oil

Beverages:

Coffee products

Alcohols:

Fermented alcohols:

Wine:

Red wine

Infusions:

Tea products

Physico-Chemical Properties - Experimental

Property	Value	Reference
Physical state	Solid
Physical Description	Not Available
Mass Composition	C 57.14%; H 4.80%; O 38.06%	DFC
Melting Point	Mp 210°	DFC
Boiling Point	Not Available
Experimental Water Solubility	1.5 mg/mL at 14 oC	YALKOWSKY,SH & DANNENFELSER,RM (1992)
Experimental logP	1.43	HANSCH,C ET AL. (1995)
Experimental pKa	pKa2 9.39 (25°)	DFC
Isoelectric point	Not Available
Charge	Not Available
Optical Rotation	Not Available
Spectroscopic UV Data	Not Available
Density	Not Available
Refractive Index	Not Available

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-0gb9-6900000000-c13506201c3612fc7ca5	Spectrum
GC-MS	Vanillic acid, 2 TMS, GC-MS Spectrum	splash10-0hp2-2691000000-8409d9c758b023c6576b	Spectrum
GC-MS	Vanillic acid, non-derivatized, GC-MS Spectrum	splash10-0gb9-2900000000-ccd8d4a214bc1a7f08c5	Spectrum
GC-MS	Vanillic acid, non-derivatized, GC-MS Spectrum	splash10-0hp2-2691000000-8409d9c758b023c6576b	Spectrum
GC-MS	Vanillic acid, non-derivatized, GC-MS Spectrum	splash10-0g0b-2981000000-a58243e35d1e3a64d2aa	Spectrum
Predicted GC-MS	Vanillic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0g4i-1900000000-851f4a1738be8dd91d47	Spectrum
Predicted GC-MS	Vanillic acid, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00dj-7390000000-18c5f822b380ea00aa26	Spectrum
Predicted GC-MS	Vanillic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Vanillic acid, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Vanillic acid, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Vanillic acid, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Vanillic acid, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Vanillic acid, TBDMS_2_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Negative (Annotated)	splash10-0gb9-0900000000-0aa6709c16899e222086	Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Negative (Annotated)	splash10-0a4i-0900000000-9aa2b9d4aa89e6ac12ab	Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Negative (Annotated)	splash10-0a4i-0900000000-6d98ebfa89f4b8ee1e6b	Spectrum
MS/MS	LC-MS/MS Spectrum - EI-B (HITACHI M-80) , Positive	splash10-0gb9-2900000000-babed327a6e49c6f7d51	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-014i-0900000000-105f33777cee542cf6df	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-05fr-1900000000-a502792703fa2f211035	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-0a4l-5900000000-037ef32f4c68a5252b92	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-0a4i-9800000000-ecd60ac022f5fee1d5ef	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-066u-9300000000-c63f7f792794f3c748a0	Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF , Negative	splash10-014i-0923211100-7e9f357f7429cff05524	Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 20V, Negative	splash10-014i-0923211100-7e9f357f7429cff05524	Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF , Negative	splash10-0a4i-0429110000-57f8760ce65d48cdc01f	Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 10V, Negative	splash10-0a4i-0429110000-57f8760ce65d48cdc01f	Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF , Negative	splash10-014i-0923211100-7e9f357f7429cff05524	Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 20V, Negative	splash10-0a4i-0900000000-8e112ffa4dcc7c08b0fd	Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF , Negative	splash10-0a4i-0429110000-57f8760ce65d48cdc01f	Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 10V, Negative	splash10-0uxr-0900000000-29a2674dccd1fa478bd5	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-014i-0900000000-105f33777cee542cf6df	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-05fr-1900000000-c4ce596998934098267b	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-014i-0900000000-342964fa3647815dd1d2	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0uxr-0900000000-f16c365899f9d95733d3	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0zfs-5900000000-e5593db0a935e1534bc6	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-014i-0900000000-6a1a2db582acd95348ea	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0600-0900000000-eda6cfe601d63ed00f8d	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0a4i-6900000000-b2c1e3f6b255e94a10af	Spectrum

NMR

Type	Description	View
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
2D NMR	[1H,13C] 2D NMR Spectrum	Spectrum

External Links

ChemSpider ID

ChEMBL ID

KEGG Compound ID

Pubchem Compound ID

Pubchem Substance ID

Not Available

ChEBI ID

Phenol-Explorer ID

DrugBank ID

HMDB ID

CRC / DFC (Dictionary of Food Compounds) ID

BJS05-K:BJS01-G

EAFUS ID

3829

Dr. Duke ID

4-HYDROXY-3-METHOXY-BENZOIC-ACID|VANILLIC-ACID

BIGG ID

Not Available

KNApSAcK ID

C00002682

HET ID

Not Available

Food Biomarker Ontology

Not Available

VMH ID

Not Available

Flavornet ID

Not Available

GoodScent ID

rw1051611

SuperScent ID

Not Available

Wikipedia ID

Phenol-Explorer Metabolite ID

414

Duplicate IDS

Not Available

Old DFC IDS

Not Available

Associated Foods

Food	Content Range	Average	Reference
Food			Reference

Biological Effects and Interactions

Health Effects / Bioactivities

Descriptor	ID	Definition	Reference
aldose reductase inhibitor	48550	An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21).	DUKE
allelopathic			DUKE
anti helmintic	33281	A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.	DUKE
anti bacterial	33282	A substance that kills or slows the growth of bacteria.	DUKE
anti cancer	35610	A substance that inhibits or prevents the proliferation of neoplasms.	DUKE
anti fatigue	52217	Any substance introduced into a living organism with therapeutic or diagnostic purpose.	DUKE
anti inflammatory	35472	A substance that reduces or suppresses inflammation.	DUKE
anti leukemic	35610	A substance that inhibits or prevents the proliferation of neoplasms.	DUKE
antioxidant	22586	A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324.	DUKE
anti peroxidant			DUKE
anti radicular			DUKE
anti septic	33281	A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.	DUKE
anti sickling			DUKE
antitumor	35610	A substance that inhibits or prevents the proliferation of neoplasms.	DUKE
antitumor promoter	35610	A substance that inhibits or prevents the proliferation of neoplasms.	DUKE
ascaricide	33281	A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.	DUKE
cancer preventive	35610	A substance that inhibits or prevents the proliferation of neoplasms.	DUKE
choleretic			DUKE
fungicide	24127	A substance used to destroy fungal pests.	DUKE
immunosuppressant	35705	An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.	DUKE
laxative	50503	An agent that produces a soft formed stool, and relaxes and loosens the bowels, typically used over a protracted period, to relieve constipation. Compare with cathartic, which is a substance that accelerates defecation. A substances can be both a laxative and a cathartic.	DUKE
pesticide	25944	Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.	DUKE
ubiquiot			DUKE

Enzymes

Not Available

Pathways

Not Available

Metabolism

Not Available

Biosynthesis

Not Available

Organoleptic Properties

Flavours

Flavor	Citations
dairy	The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
milky	The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
sweet	The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
creamy	The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
powdery	The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
vanilla	The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
bean	The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.