Record Information |
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Version | 1.0 |
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Creation date | 2010-04-08 22:05:26 UTC |
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Update date | 2020-09-17 15:31:12 UTC |
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Primary ID | FDB002593 |
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Secondary Accession Numbers | Not Available |
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Chemical Information |
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FooDB Name | p-Coumaric acid |
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Description | trans-4-Coumaric acid or (e)-p-Coumaric acid, the trans-isomer of 4-coumaric acid, also known as 4-hydroxycinnamic acid, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing a cinnamic acid where the benzene ring is hydroxylated. 4-Hydroxycinnamic acid is a neutral compound. 4-Hydroxycinnamic acid exists in all living species, from bacteria to humans. 4-Hydroxycinnamic acid is found in highest concentrations in pepper (c. frutescens), pineapples, and sunflowers and in lower concentration in spinachs, kiwis, and sweet oranges. 4-Hydroxycinnamic acid has also been detected in wild rices, soursops, garden onions, hyssops, and avocado. This could make 4-hydroxycinnamic acid a potential biomarker for the consumption of these foods. |
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CAS Number | 7400-08-0 |
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Structure | |
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Synonyms | Synonym | Source |
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(2E)-3-(4-Hydroxyphenyl)acrylic acid | ChEBI | (e)-3-(4-Hydroxyphenyl)-2-propenoic acid | ChEBI | (e)-p-Coumaric acid | ChEBI | (e)-p-Hydroxycinnamic acid | ChEBI | 4'-HYDROXYCINNAMIC ACID | ChEBI | Naringeninic acid | ChEBI | p-Coumaric acid | ChEBI | trans-p-Coumaric acid | ChEBI | trans-p-Coumarinic acid | ChEBI | trans-p-Hydroxycinnamate | ChEBI | trans-p-Hydroxycinnamic acid | ChEBI | trans-4-Hydroxycinnamate | Kegg | 4-Hydroxycinnamate | Kegg | (2E)-3-(4-Hydroxyphenyl)acrylate | Generator | (e)-3-(4-Hydroxyphenyl)-2-propenoate | Generator | (e)-p-Coumarate | Generator | (e)-p-Hydroxycinnamate | Generator | 4'-HYDROXYCINNAMate | Generator | Naringeninate | Generator | p-Coumarate | Generator | trans-p-Coumarate | Generator | trans-p-Coumarinate | Generator | 4-Coumaric acid, (e)-isomer | MeSH | 4-Coumaric acid, (Z)-isomer | MeSH | 4-Coumaric acid, disodium salt | MeSH | p-Coumaryl alcohol | MeSH | p-Hydroxycinnamic acid | MeSH | Para-coumaric acid | MeSH | trans-3-(4'-Hydroxyphenyl)-2-propenoic acid | MeSH | trans-HPPA | MeSH | 3-(4-Hydroxyphenyl)-2-propenoate | HMDB | 3-(4-Hydroxyphenyl)-2-propenoic acid | HMDB | 3-(4-Hydroxyphenyl)acrylate | HMDB | 3-(4-Hydroxyphenyl)acrylic acid | HMDB | 4-Coumarate | HMDB | 4-Hydroxy cinnamate | HMDB | 4-Hydroxy cinnamic acid | HMDB | 4-Hydroxyphenylpropenoate | HMDB | 4-Hydroxyphenylpropenoic acid | HMDB | b-[4-Hydroxyphenyl]acrylate | HMDB | b-[4-Hydroxyphenyl]acrylic acid | HMDB | beta-[4-Hydroxyphenyl]acrylate | HMDB | beta-[4-Hydroxyphenyl]acrylic acid | HMDB | cis-P-Coumarate | HMDB | Hydroxycinnamate | HMDB | Hydroxycinnamic acid | HMDB | P-Cumarate | HMDB | P-Cumaric acid | HMDB | P-Hydroxycinnamate | HMDB | P-Hydroxyphenylacrylate | HMDB | P-Hydroxyphenylacrylic acid | HMDB | Para coumarate | HMDB | Para coumaric acid | HMDB | Para-coumarate | HMDB | 4-Hydroxycinnamic acid | ChEBI | trans-4-Coumarate | Generator, HMDB | (2E)-3-(4-Hydroxyphenyl)-2-propenoic acid | HMDB | (2E)-3-(4-Hydroxyphenyl)prop-2-enoic acid | HMDB | (E)-3-(4-Hydroxyphenyl)acrylic acid | HMDB | (E)-4-Hydroxycinnamic acid | HMDB | 4’-Hydroxycinnamic acid | HMDB | p-Cumaric acid | HMDB | p-Hydroxy-trans-cinnamic acid | HMDB | p-Hydroxyphenylacrylic acid | HMDB | p-trans-Coumaric acid | HMDB | trans-3-(4-Hydroxyphenyl)-2-propenoic acid | HMDB | trans-4-Coumaric acid | HMDB | β-[4-Hydroxyphenyl]acrylic acid | HMDB | (2e)-3-(4-Hydroxyphenyl)acrylate | Generator | (2e)-3-(4-Hydroxyphenyl)acrylic acid | ChEBI | (e)-P-Coumarate | Generator | (e)-P-Hydroxycinnamate | Generator | 4-Coumaric acid | biospider | p-Cumarate | biospider | p-Hydroxy-cinnamic acid | biospider | p-Hydroxycinnamate | biospider | P-Hydroxycinnamic acid | HMDB | p-Hydroxycinnamic acid, 8CI | db_source | p-Hydroxyphenylacrylate | biospider | para-Coumarate | biospider | para-Coumaric acid | biospider | trans-P-Coumarinate | Generator |
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Predicted Properties | |
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Chemical Formula | C9H8O3 |
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IUPAC name | (2E)-3-(4-hydroxyphenyl)prop-2-enoic acid |
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InChI Identifier | InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+ |
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InChI Key | NGSWKAQJJWESNS-ZZXKWVIFSA-N |
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Isomeric SMILES | OC(=O)\C=C\C1=CC=C(O)C=C1 |
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Average Molecular Weight | 164.158 |
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Monoisotopic Molecular Weight | 164.047344122 |
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Classification |
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Description | Belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. |
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Kingdom | Organic compounds |
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Super Class | Phenylpropanoids and polyketides |
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Class | Cinnamic acids and derivatives |
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Sub Class | Hydroxycinnamic acids and derivatives |
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Direct Parent | Hydroxycinnamic acids |
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Alternative Parents | |
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Substituents | - Cinnamic acid
- Coumaric acid
- Coumaric acid or derivatives
- Hydroxycinnamic acid
- Styrene
- 1-hydroxy-2-unsubstituted benzenoid
- Phenol
- Monocyclic benzene moiety
- Benzenoid
- Carboxylic acid derivative
- Carboxylic acid
- Monocarboxylic acid or derivatives
- Organic oxide
- Organic oxygen compound
- Hydrocarbon derivative
- Organooxygen compound
- Carbonyl group
- Aromatic homomonocyclic compound
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Molecular Framework | Aromatic homomonocyclic compounds |
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External Descriptors | |
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Ontology |
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Disposition | Route of exposure: Source: Biological location: |
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Role | Biological role: Industrial application: |
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Foods | Cocoa and cocoa products Grains: Nuts and legumes: Fruits and vegetables: Fats and oils: Beverages: |
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Physico-Chemical Properties |
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Physico-Chemical Properties - Experimental | Property | Value | Reference |
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Physical state | Solid | |
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Physical Description | Not Available | |
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Mass Composition | C 65.85%; H 4.91%; O 29.24% | DFC |
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Melting Point | 211.5 oC | |
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Boiling Point | Not Available | |
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Experimental Water Solubility | Not Available | |
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Experimental logP | 1.79 | SANGSTER (1994) |
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Experimental pKa | 4.64 | |
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Isoelectric point | Not Available | |
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Charge | Not Available | |
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Optical Rotation | Not Available | |
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Spectroscopic UV Data | Not Available | |
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Density | Not Available | |
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Refractive Index | Not Available | |
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Spectra |
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Spectra | |
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EI-MS/GC-MS | Type | Description | Splash Key | View |
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EI-MS | Mass Spectrum (Electron Ionization) | splash10-03xr-6900000000-348f5c7c030570e0612f | 2015-03-01 | View Spectrum | GC-MS | p-Coumaric acid, non-derivatized, GC-MS Spectrum | splash10-014m-1981000000-e7648e85764a445a919c | Spectrum | GC-MS | p-Coumaric acid, 2 TMS, GC-MS Spectrum | splash10-066v-3791000000-a5712bbe8401ef499b5a | Spectrum | GC-MS | p-Coumaric acid, non-derivatized, GC-MS Spectrum | splash10-03di-8900000000-3bb023f80c1f54a16adc | Spectrum | GC-MS | p-Coumaric acid, non-derivatized, GC-MS Spectrum | splash10-03xr-5900000000-a364c62c9122c0fbe6de | Spectrum | GC-MS | p-Coumaric acid, non-derivatized, GC-MS Spectrum | splash10-014m-1981000000-e7648e85764a445a919c | Spectrum | GC-MS | p-Coumaric acid, non-derivatized, GC-MS Spectrum | splash10-066v-3791000000-a5712bbe8401ef499b5a | Spectrum | GC-MS | p-Coumaric acid, non-derivatized, GC-MS Spectrum | splash10-014m-1891000000-d8804981d3918cac534d | Spectrum | Predicted GC-MS | p-Coumaric acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive | splash10-014j-2900000000-7075c3e10f9df528109e | Spectrum | Predicted GC-MS | p-Coumaric acid, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive | splash10-00xu-6390000000-3110f0f6eb462a38bb64 | Spectrum | Predicted GC-MS | p-Coumaric acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive | Not Available | Spectrum |
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MS/MS | Type | Description | Splash Key | View |
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MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative | splash10-03di-0900000000-b58aab08954c973df04e | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative | splash10-014i-0900000000-3ddb41572ba36a950e37 | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative | splash10-014i-0900000000-ccac7f071084bc660095 | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative | splash10-014i-3900000000-5dc8af06da0120779cff | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative | splash10-00kf-9500000000-9187edc4498ab4345e5a | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative | splash10-014i-0900000000-3d831c6acd9d3188de2f | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative | splash10-03di-0900000000-fbb6439b7d012045f3a8 | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Negative | splash10-0002-0900000000-9e18d43a8d86f9b9e72b | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - DI-ESI-qTof , Negative | splash10-014i-0900000000-c45397049a7ba500b332 | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , negative | splash10-03di-0900000000-b58aab08954c973df04e | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , negative | splash10-014i-0900000000-3ddb41572ba36a950e37 | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , negative | splash10-014i-0900000000-ccac7f071084bc660095 | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , negative | splash10-014i-3900000000-5dc8af06da0120779cff | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QQ , negative | splash10-00kf-9500000000-9187edc4498ab4345e5a | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QTOF , negative | splash10-014i-0900000000-3d831c6acd9d3188de2f | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QTOF , negative | splash10-03di-0900000000-fbb6439b7d012045f3a8 | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QTOF , negative | splash10-0002-0900000000-9e18d43a8d86f9b9e72b | 2017-09-14 | View Spectrum | MS/MS | LC-MS/MS Spectrum - 10V, Negative | splash10-03di-0900000000-c6491d0aaba639e3ae07 | 2021-09-20 | View Spectrum | MS/MS | LC-MS/MS Spectrum - 30V, Negative | splash10-0002-0900000000-9e18d43a8d86f9b9e72b | 2021-09-20 | View Spectrum | MS/MS | LC-MS/MS Spectrum - 35V, Negative | splash10-014i-0900000000-a183cce49af676c95d4e | 2021-09-20 | View Spectrum | MS/MS | LC-MS/MS Spectrum - 20V, Negative | splash10-014i-0900000000-1f13fa0e7a24be298cfb | 2021-09-20 | View Spectrum | MS/MS | LC-MS/MS Spectrum - 40V, Negative | splash10-00kf-9200000000-206402014014906dbe29 | 2021-09-20 | View Spectrum | MS/MS | LC-MS/MS Spectrum - EI-B (HITACHI M-52) , Positive | splash10-03di-8900000000-3bb023f80c1f54a16adc | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive | splash10-00kb-3900000000-1118928776a5a6e213db | 2012-08-31 | View Spectrum | MS/MS | LC-MS/MS Spectrum - DI-ESI-qTof , Positive | splash10-0002-0900000000-c5faa58d353ca1466c3c | 2017-09-14 | View Spectrum |
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NMR | Type | Description | | View |
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1D NMR | 1H NMR Spectrum (1D, DMSO, experimental) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, DMSO, experimental) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 100 MHz, H2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 100 MHz, H2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 1000 MHz, H2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 1000 MHz, H2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 200 MHz, H2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 200 MHz, H2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 300 MHz, H2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 300 MHz, H2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 400 MHz, H2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 400 MHz, H2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 500 MHz, H2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 500 MHz, H2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 600 MHz, H2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 600 MHz, H2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 700 MHz, H2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 700 MHz, H2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 800 MHz, H2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 800 MHz, H2O, predicted) | | Spectrum | 1D NMR | 13C NMR Spectrum (1D, 900 MHz, H2O, predicted) | | Spectrum | 1D NMR | 1H NMR Spectrum (1D, 900 MHz, H2O, predicted) | | Spectrum |
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External Links |
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ChemSpider ID | 553148 |
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ChEMBL ID | CHEMBL66879 |
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KEGG Compound ID | C00811 |
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Pubchem Compound ID | 637542 |
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Pubchem Substance ID | Not Available |
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ChEBI ID | Not Available |
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Phenol-Explorer ID | 500 |
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DrugBank ID | DB04066 |
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HMDB ID | HMDB02035 |
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CRC / DFC (Dictionary of Food Compounds) ID | CMP73-U:CMP73-U |
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EAFUS ID | Not Available |
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Dr. Duke ID | 4-HYDROXYCINNAMIC-ACID|P-COUMARIC-ACID|P-HYDROXYCINNAMIC-ACID |
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BIGG ID | 36077 |
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KNApSAcK ID | C00000152 |
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HET ID | HC4 |
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Food Biomarker Ontology | Not Available |
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VMH ID | Not Available |
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Flavornet ID | Not Available |
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GoodScent ID | Not Available |
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SuperScent ID | Not Available |
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Wikipedia ID | Coumaric_acid |
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Phenol-Explorer Metabolite ID | 454 |
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Duplicate IDS | Not Available |
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Old DFC IDS | Not Available |
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Associated Foods |
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Food | Content Range | Average | Reference |
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Food | | | Reference |
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Biological Effects and Interactions |
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Health Effects / Bioactivities | Descriptor | ID | Definition | Reference |
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Aldose reductase inhibitor | 48550 | An agent that blocks the activity of aldose reductase, an enzyme involved in glucose metabolism. It reduces oxidative stress and inflammation, commonly used in managing diabetic complications, such as neuropathy, nephropathy, and retinopathy. | DUKE | Allelopathic | | Biochemicals that inhibit growth, survival, or reproduction in other organisms, with potential therapeutic applications in weed control, antimicrobial, and anticancer treatments, and key medical uses in developing novel pesticides, antibiotics, and chemotherapeutics. | DUKE | Anti bacterial | 33282 | An agent that inhibits the growth of or destroys bacteria, playing a crucial role in preventing and treating infections. Therapeutically, it is used to combat bacterial infections, with key medical applications including treating pneumonia, tuberculosis, and skin infections, as well as preventing surgical site infections and sepsis. | DUKE | Anti-clastogen | | An agent that inhibits mutagenic agents, preventing chromosome breakage and disruption, used to reduce genetic damage and cancer risk, with therapeutic applications in cancer prevention and treatment, and key medical uses in protecting against radiation and chemical-induced DNA damage. | DUKE | Anti-fertility | | An agent that inhibits reproduction, playing a biological role in population control. Therapeutically, it's used as a contraceptive, with key medical applications in family planning and birth control, preventing unwanted pregnancies and managing reproductive health. | DUKE | Anti hepatotoxic | 62868 | An agent that protects the liver from damage, reducing toxicity and promoting liver health. It plays a biological role in preventing liver injury and supporting liver function. Therapeutically, it is used to treat liver diseases, such as hepatitis and cirrhosis, and to counteract liver-damaging effects of certain medications and toxins. | DUKE | Anti leukemic | 35610 | An agent that targets and inhibits the growth of leukemia cells, playing a crucial role in cancer treatment. Therapeutically, it is used to induce remission, manage symptoms, and improve survival rates in patients with leukemia. Key medical uses include treating acute and chronic leukemia, lymphoma, and other hematological malignancies. | DUKE | Anti-nitrosaminic | | An agent that inhibits the formation of nitrosamines, carcinogenic compounds. It plays a biological role in cancer prevention, with therapeutic applications in reducing the risk of tobacco-related and other cancers. Key medical uses include chemoprevention and protection against carcinogenic exposures. | DUKE | Anti-oxidant | 22586 | An agent that neutralizes free radicals, reducing oxidative stress and cell damage. Its biological role involves protecting cells from harm, and it has therapeutic applications in managing chronic diseases, such as cancer, diabetes, and neurodegenerative disorders, with key medical uses including anti-aging, anti-inflammatory, and cardio protective effects. | DUKE | Anti peroxidant | | An agent that prevents oxygen atom and peroxide formation, reducing oxidative stress and cell damage. It plays a biological role in protecting cells from free radicals. Therapeutically, it's used to manage conditions like cancer, Alzheimer's, and atherosclerosis, with key medical applications in neuroprotection, cardiovascular health, and anti-aging. | DUKE | Anti septic | 33281 | An agent that prevents or reduces the growth of microorganisms, such as bacteria, fungi, or viruses, to promote wound healing and prevent infection. Therapeutically, anti septics are used to treat minor cuts, scrapes, and burns, and are commonly applied topically to reduce the risk of infection and promote tissue repair. Key medical uses include wound care, surgical site preparation, and skin infection management. | DUKE | Anti-spasmodic | 52217 | An agent that relaxes smooth muscle, reducing muscle spasms and cramps. It plays a biological role in regulating muscle tone and is therapeutically applied to treat conditions such as irritable bowel syndrome, menstrual cramps, and muscle spasms, providing relief from abdominal pain and discomfort. | DUKE | Antitumor | 35610 | An agent that inhibits tumor growth and proliferation, playing a crucial role in cancer treatment. Therapeutically, antitumors are used to manage various types of cancer, including chemotherapy, targeted therapy, and immunotherapy, helping to reduce tumor size, prevent metastasis, and improve patient outcomes. | DUKE | Cancer preventive | 35610 | An agent that inhibits the development and progression of cancer, reducing tumor formation and growth. It plays a biological role in blocking carcinogenic pathways, and has therapeutic applications in chemoprevention. Key medical uses include reducing the risk of cancer in high-risk individuals and preventing cancer recurrence. | DUKE | Chemopreventive | 35610 | An agent that prevents or delays the development of cancer, reducing the risk of tumor formation and progression. It plays a biological role in inhibiting carcinogenesis, and has therapeutic applications in cancer prevention, with key medical uses including reducing the risk of colorectal, breast, and prostate cancers. | DUKE | Choleretic | | An agent that increases bile production and secretion from the liver, enhancing digestion and fat absorption. Therapeutically, it's used to treat gallstones, liver disease, and indigestion, promoting healthy bile flow and liver function. | DUKE | Cytotoxic | 52209 | An agent that kills or damages cells, playing a biological role in immune responses and therapeutic applications in cancer treatment. Key medical uses include chemotherapy, targeting and destroying cancer cells, and treating certain autoimmune diseases by eliminating harmful cells. | DUKE | Diaphoretic | | An agent that induces perspiration, playing a biological role in thermoregulation. Therapeutically, it's used to treat fever, detoxify, and relieve congestion. Key medical uses include managing hyperthermia, aiding in toxin removal, and alleviating symptoms of colds and flu. | DUKE | Fungicide | 24127 | An agent that kills or inhibits the growth of fungi, playing a biological role in preventing fungal infections. Therapeutically, it is used to treat fungal diseases, with key medical applications including athlete's foot, ringworm, and candidiasis, as well as agricultural uses to protect crops from fungal damage. | DUKE | Lipoxygenase inhibitor | 35856 | An agent that blocks the activity of lipoxygenase enzymes, reducing inflammation and oxidative stress. Therapeutically, it's used to manage conditions like asthma, atherosclerosis, and cancer, by inhibiting the production of pro-inflammatory leukotrienes. Key medical uses include treating respiratory and cardiovascular diseases. | DUKE | Pesticide | 25944 | An agent that kills or repels pests, playing a biological role in controlling insect, weed, and fungal populations. Therapeutically, pesticides have limited applications, but some are used to treat ectoparasitic infestations, such as lice and scabies. Key medical uses include topical treatments for head lice and scabies, highlighting their role in managing parasitic infections. | DUKE | Prostaglandigenic | | An agent that promotes the production of prostaglandins, which are hormonelike compounds that stimulate uterine contractions, among other effects. Therapeutically, prostaglandigenic agents are used to induce labor, manage postpartum hemorrhage, and treat certain gynecological conditions, showcasing their key role in obstetrics and women's health. | DUKE | Prostaglandin synthesis inhibitor | 35222 | An agent that blocks the production of prostaglandins, reducing inflammation and pain. Therapeutically, it's used to treat conditions like arthritis, menstrual cramps, and fever, commonly found in nonsteroidal anti-inflammatory drugs (NSAIDs). | DUKE | Tyrosinase inhibitor | 59997 | An agent that blocks the activity of tyrosinase, an enzyme involved in melanin production, reducing skin pigmentation. Therapeutically used to treat hyperpigmentation disorders, such as melasma and vitiligo, and as a skin-lightening agent in dermatology. | DUKE |
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Enzymes | Not Available |
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Pathways | Not Available |
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Metabolism | Not Available |
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Biosynthesis | Not Available |
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Organoleptic Properties |
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Flavours | Not Available |
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Files |
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MSDS | show |
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References |
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Synthesis Reference | Not Available |
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General Reference | Not Available |
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Content Reference | — Rothwell JA, Pérez-Jiménez J, Neveu V, Medina-Ramon A, M'Hiri N, Garcia Lobato P, Manach C, Knox K, Eisner R, Wishart D, Scalbert A. (2013) Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database, 10.1093/database/bat070. — Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004). — Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.
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