Record Information
Creation date2010-04-08 22:05:28 UTC
Update date2019-11-26 02:57:48 UTC
Primary IDFDB002679
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameHesperetin 7-neohesperidoside
DescriptionHesperetin 7-neohesperidoside belongs to the class of organic compounds known as cyclobutane lignans. These are lignans with a structure characterized by to phenylpropanoid units coupled together through the C7-C7' and C8-C8' bonds, forming a cyclobutane ring with the C7, C7', C8', and C8 atoms. Hesperetin 7-neohesperidoside is found, on average, in the highest concentration within a few different foods, such as grapefruits (Citrus X paradisi), grapefruit/pummelo hybrids (Citrus paradisi X Citrus maxima), and lemons (Citrus limon) and in a lower concentration in sweet oranges (Citrus sinensis). Hesperetin 7-neohesperidoside has also been detected, but not quantified in, several different foods, such as citrus, limes (Citrus aurantiifolia), mandarin orange (clementine, tangerine), and pummelos (Citrus maxima). This could make hesperetin 7-neohesperidoside a potential biomarker for the consumption of these foods. Based on a literature review very few articles have been published on Hesperetin 7-neohesperidoside.
CAS Number13241-33-3
Hesperetin 7-O-neohesperidosideHMDB
Hesperetin 7-neohesperidosidedb_source
Predicted Properties
Water Solubility3.37 g/LALOGPS
pKa (Strongest Acidic)8.61ChemAxon
pKa (Strongest Basic)-3.6ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count15ChemAxon
Hydrogen Donor Count8ChemAxon
Polar Surface Area234.29 ŲChemAxon
Rotatable Bond Count7ChemAxon
Refractivity140.77 m³·mol⁻¹ChemAxon
Polarizability60.79 ųChemAxon
Number of Rings5ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Chemical FormulaC28H34O15
IUPAC name7-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
InChI IdentifierInChI=1S/C28H34O15/c1-10-21(33)23(35)25(37)27(39-10)43-26-24(36)22(34)19(9-29)42-28(26)40-12-6-14(31)20-15(32)8-17(41-18(20)7-12)11-3-4-16(38-2)13(30)5-11/h3-7,10,17,19,21-31,33-37H,8-9H2,1-2H3
Average Molecular Weight610.5606
Monoisotopic Molecular Weight610.189770418
Description Belongs to the class of organic compounds known as cyclobutane lignans. These are lignans with a structure characterized by to phenylpropanoid units coupled together through the C7-C7' and C8-C8' bonds, forming a cyclobutane ring with the C7, C7', C8', and C8 atoms.
KingdomOrganic compounds
Super ClassLignans, neolignans and related compounds
ClassCyclobutane lignans
Sub ClassNot Available
Direct ParentCyclobutane lignans
Alternative Parents
  • Cyclobutane lignan skeleton
  • Dibenzylbutane lignan skeleton
  • Stilbene
  • Phenoxy compound
  • Methoxybenzene
  • Phenol ether
  • Anisole
  • Alkyl aryl ether
  • Benzenoid
  • Monocyclic benzene moiety
  • Ether
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available

Route of exposure:


Biological location:


Industrial application:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionC 55.08%; H 5.61%; O 39.31%DFC
Melting PointMp 244°DFC
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical Rotation[a]D -100 (c, 0.5 in Py)DFC
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
TypeDescriptionSplash KeyView
GC-MSHesperetin 7-neohesperidoside, non-derivatized, GC-MS Spectrumsplash10-014j-0930000000-e06187b94b91bece73ebSpectrum
GC-MSHesperetin 7-neohesperidoside, non-derivatized, GC-MS Spectrumsplash10-014j-0930000000-e06187b94b91bece73ebSpectrum
Predicted GC-MSHesperetin 7-neohesperidoside, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0595-7211090000-ad27da094f49ce125ea4Spectrum
Predicted GC-MSHesperetin 7-neohesperidoside, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0lk9-9311018000-7c8542e0ec6068c1b53eSpectrum
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - LC-ESI-TOF , negativesplash10-0a4i-0000009000-22f8094c7ada8928b6942017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-TOF , negativesplash10-0a4i-0003009000-68522ebdb396405fee532017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-TOF , negativesplash10-0a4i-0000009000-04cc3791b0a80ce12a352017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-TOF , negativesplash10-0udi-0009001000-a784d35122c71c756b902017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0a4i-0000009000-f7ccd876e0275858b7842021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0udi-0009000000-19148a209130a5aa898c2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0udi-0439501000-9b8f76f75a3bb45c37942021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0w29-0961000000-70b0466bf27ab8ba54602021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0udi-0009000000-8d4547c9300481f47b642021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0w29-0961000000-f28f6c5de90993cbc0172021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0a4i-0000009000-3c9b3e61420c62c3ef5e2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0a4i-0000009000-5389085d4e4a4c9388322021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0udi-0009000000-560c9f79f2b1714bb14a2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Negativesplash10-0pb9-0006009000-84cd0bf5ac7208a8b6db2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0udi-0439501000-3bd1a33265783be93f7b2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0w29-0960000000-a8efbff7c5c9972af64c2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0pb9-0017009000-97193b5009abc913a2dc2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0pb9-0017009000-de07800bc91724543b912021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0pb9-0006009000-de6a04d7ce700b9463a82021-09-20View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0udj-0337932000-4f816481d88bc4dc284a2015-04-24View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0udr-0469400000-61a492d660c6ac50cab22015-04-24View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0udi-1945000000-a59da63ead1fe09512142015-04-24View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0r01-4639756000-940018a6761f4084c98a2015-04-25View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0w2a-2947520000-9e4e51caf6c79a3d2ddc2015-04-25View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0udi-9757000000-cad4fecc590b2576b2fb2015-04-25View Spectrum
NMRNot Available
ChemSpider ID203119
ChEMBL IDNot Available
KEGG Compound IDC09806
Pubchem Compound ID232990
Pubchem Substance IDNot Available
ChEBI ID59016
Phenol-Explorer ID211
DrugBank IDNot Available
CRC / DFC (Dictionary of Food Compounds) IDCNB06-R:CNB11-P
EAFUS IDNot Available
BIGG IDNot Available
KNApSAcK IDC00000987
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDNot Available
Phenol-Explorer Metabolite ID211
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
Biological Effects and Interactions
Health Effects / Bioactivities
anti cancer35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
antioxidant22586 A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324.DUKE
anti radicularDUKE
antitumor promoter35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
cancer preventive35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
MSDSNot Available
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Rothwell JA, Pérez-Jiménez J, Neveu V, Medina-Ramon A, M'Hiri N, Garcia Lobato P, Manach C, Knox K, Eisner R, Wishart D, Scalbert A. (2013) Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database, 10.1093/database/bat070.
— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).