1.02010-04-08 22:06:05 UTC2019-11-26 02:59:48 UTCFDB004090AtropineAtropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure. Atropine is found in burdock.(±)-atropine(±)-hyoscyamine(+-)-atropine(+-)-hyoscyamine(+,-)-tropyl tropate(+,-)-Tropyl tropic acid(+/-)-atropine(+/-)-hyoscyamine(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate(3-Endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropic acid[(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate[(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoic acid1-α-H,5-α-H-Tropan-3-α-ol (.+/-.)-tropate1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester)1αH,5αH-Tropan-3α-ol (±)-tropate1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester)2-Phenylhydracrylic acid 3-α-tropanyl ester2-Phenylhydracrylic acid 3-alpha-tropanyl ester51-55-8 (FREE BASE)5908-99-6 (SULFATE(2:1), MONOHYDRATE)8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoic acid8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropic acidAnaspazAtnaaAtropenAtropen (TN)AtropinAtropin-flexiolenAtropinaAtropineAtropine (usp)Atropine [ban]Atropine Ont 1%Atropine sulfateAtropine sulfate ansyr plastic syringeAtropinolAtropinumAtropisolAtroptBelladenalBellergal-sButibelCytospazDL-hyoscyamineDL-Tropanyl 2-hydroxy-1-phenylpropionateDL-tropyl tropateDL-tropyltropateDL-Tropyltropic acidDonnagelDonnatalEyesulesHycodanHyoscyamineHyoscyamine sulfateIsopto Atropine 1%Isopto-atropineLomotilLonoxMinimsMinims Atropine Sulphate 1%Neo-diophenProtamine + atropineProtamine and atropinetropan-3alpha-yl 3-hydroxy-2-phenylpropanoateTropic acid, 3-α-tropanyl esterTropic acid, 3-alpha-tropanyl esterTropic acid, ester with tropineTropine (+/-)-tropateTropine tropateTropine tropic acidTropine, tropate (ester)Troyl tropateUrisedC17H23NO3289.3694289.1677936078-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate()-hyoscyamine51-55-8CN1C2CCC1CC(C2)OC(=O)C(CO)C1=CC=CC=C1InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3RKUNBYITZUJHSG-UHFFFAOYSA-N belongs to the class of organic compounds known as tropane alkaloids. These are organic compounds containing the nitrogenous bicyclic alkaloid parent N-Methyl-8-azabicyclo[3.2.1]octane.Tropane alkaloidsOrganic compoundsAlkaloids and derivativesTropane alkaloidsAromatic heteropolycyclic compoundsAmino acids and derivativesAzacyclic compoundsBenzene and substituted derivativesBeta hydroxy acids and derivativesCarbonyl compoundsCarboxylic acid estersHydrocarbon derivativesMonocarboxylic acids and derivativesN-alkylpyrrolidinesOrganic oxidesOrganopnictogen compoundsPiperidinesPrimary alcoholsTrialkylaminesAlcoholAmineAmino acid or derivativesAromatic heteropolycyclic compoundAzacycleBenzenoidBeta-hydroxy acidCarbonyl groupCarboxylic acid derivativeCarboxylic acid esterHydrocarbon derivativeHydroxy acidMonocarboxylic acid or derivativesMonocyclic benzene moietyN-alkylpyrrolidineOrganic nitrogen compoundOrganic oxideOrganic oxygen compoundOrganoheterocyclic compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundPiperidinePrimary alcoholPyrrolidineTertiary aliphatic amineTertiary amineTropane alkaloidSolidlogp2.19logs-2.06solubility2.52e+00 g/lmelting_point118.5 oClogp1.57pka_strongest_acidic15.15pka_strongest_basic9.39iupac8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoateaverage_mass289.3694mono_mass289.167793607smilesCN1C2CCC1CC(C2)OC(=O)C(CO)C1=CC=CC=C1formulaC17H23NO3inchiInChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3inchikeyRKUNBYITZUJHSG-UHFFFAOYSA-Npolar_surface_area49.77refractivity80.82polarizability31.97rotatable_bond_count5acceptor_count3donor_count1physiological_charge1formal_charge0Specdb::CMs105866Specdb::CMs117988Specdb::MsMs68496Specdb::MsMs68497Specdb::MsMs68498Specdb::MsMs126540Specdb::MsMs126541Specdb::MsMs126542Specdb::MsMs2226207Specdb::MsMs2228561Specdb::MsMs2230909Specdb::MsMs2233429Specdb::MsMs2235527Specdb::MsMs2236536Specdb::MsMs2244830Specdb::MsMs2245309Specdb::MsMs2246922Specdb::MsMs2247341Specdb::MsMs2249070Specdb::MsMs2249346Specdb::MsMs2251034Specdb::MsMs2251355Specdb::MsMs2254385Specdb::MsMs2256161Specdb::MsMs3388561Specdb::MsMs3388562Specdb::MsMs3388563HMDB1471216684#<Reference:0x0000555675b9b5b0>#<Reference:0x0000555675b9b3d0>#<Reference:0x0000555675b9b128>#<Reference:0x0000555675b9aed0>#<Reference:0x0000555675b9ad18>BurdockType 1specificArctium lappa42173.03.03.0mg/100 gallergenic43A chemical compound which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.analgesic56An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.anesthetic62anhydrotic65anti anoxic119Any substance introduced into a living organism with therapeutic or diagnostic purpose.anti arrhythmic129A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.anti asthmatic134A drug used to treat asthma.anti bradycardic151A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.anti cholinergic183Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.anti emetic253A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.anti emphysemic254Any substance introduced into a living organism with therapeutic or diagnostic purpose.anti enuretic263anti herpetic329A substance that destroys or inhibits replication of viruses.anti iritic375anti muscarinic450A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.anti Parkinsonian509A drug used in the treatment of Parkinson's disease.anti peristaltic517anti perspirant522anti pertussic523A substance that kills or slows the growth of bacteria.anti polio538A substance that destroys or inhibits replication of viruses.anti sialogogue613anti spasmodic619Any substance introduced into a living organism with therapeutic or diagnostic purpose.anti ulcer676One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract.anti uveitic684anti vertigo688Any substance introduced into a living organism with therapeutic or diagnostic purpose.anti viral689A substance that destroys or inhibits replication of viruses.antidote236Any protective agent counteracting or neutralizing the action of poisons.bronchodilator736An agent that causes an increase in the expansion of a bronchus or bronchial tubes.central nervous system depressant812A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.central nervous system stimulant816A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.choleretic801hyperpyrexic1006insecticide1040Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.mydriatic1129Agent that dilates the pupil. Used in eye diseases and to facilitate eye examination. It may be either a sympathomimetic or parasympatholytic. The latter cause cycloplegia or paralysis of accommodation at high doses and may precipitate glaucoma.myorelaxant1134neurotoxic1160A poison that interferes with the functions of the nervous system.paralytic1196pesticide1210Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.psychotomimetic1269A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.tachycardic1345A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.transdermal1374tumorigenic1388A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.vasodilator1413A drug used to cause dilation of the blood vessels.