Record Information
Version1.0
Creation date2010-04-08 22:08:08 UTC
Update date2019-11-26 03:02:46 UTC
Primary IDFDB008544
Secondary Accession NumbersNot Available
Chemical Information
FooDB Name2-Methoxy-3-(2-methylpropyl)pyrazine
Description2-Methoxy-3-(2-methylpropyl)pyrazine belongs to the class of organic compounds known as methoxypyrazines. These are pyrazines containing a methoxyl group attached to the pyrazine ring. 2-Methoxy-3-(2-methylpropyl)pyrazine is a bell, earth, and galbanum tasting compound. 2-Methoxy-3-(2-methylpropyl)pyrazine has been detected, but not quantified in, several different foods, such as pepper (c. frutescens), peppers (Capsicum annuum), herbs and spices, common grapes (Vitis vinifera), and orange bell peppers (Capsicum annuum). This could make 2-methoxy-3-(2-methylpropyl)pyrazine a potential biomarker for the consumption of these foods. Based on a literature review very few articles have been published on 2-Methoxy-3-(2-methylpropyl)pyrazine.
CAS Number24683-00-9
Structure
Thumb
Synonyms
SynonymSource
1DZKHMDB
2-Isobutyl-3-methoxy-pyrazineHMDB
2-Isobutyl-3-methoxypyrazineHMDB
2-Isobutyl-3-methoxypyrazine, 8ciHMDB
2-Methoxy-3-(2-methyl-propyl) pyrazineHMDB
2-Methoxy-3-(2-methylpropyl)-pyrazineHMDB
2-Methoxy-3-isobutylpyrazineHMDB, MeSH
3-Isobutyl-2-methoxypyrazineHMDB, MeSH
3-Methoxy-2-isobutylpyrazineHMDB
FEMA 3132HMDB
GalbazineHMDB
IBMPHMDB
PRZHMDB
Pyrazine, 2-(2-methylpropyl)-3-methoxyHMDB
Pyrazine, 2-isobutyl-3-methoxyHMDB
Pyrazine, 2-methoxy, 3-isobutylHMDB
Pyrazine, 3-methoxy-2-(2-methylpropyl)HMDB
1dzkbiospider
2-Isobutyl-3-methoxypyrazine, 8CIdb_source
2-methoxy-3-(2-methyl-propyl) pyrazinebiospider
3-methoxy-2-isobutylpyrazinebiospider
Pyrazine, 2-isobutyl-3-methoxy-biospider
Pyrazine, 2-methoxy-3-(2-methylpropyl)-biospider
pyrazine, 2-methoxy, 3-isobutylbiospider
Predicted Properties
PropertyValueSource
Water Solubility20.9 g/LALOGPS
logP2.11ALOGPS
logP1.54ChemAxon
logS-0.9ALOGPS
pKa (Strongest Basic)0.98ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area35.01 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity46.89 m³·mol⁻¹ChemAxon
Polarizability18.38 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC9H14N2O
IUPAC name2-methoxy-3-(2-methylpropyl)pyrazine
InChI IdentifierInChI=1S/C9H14N2O/c1-7(2)6-8-9(12-3)11-5-4-10-8/h4-5,7H,6H2,1-3H3
InChI KeyUXFSPRAGHGMRSQ-UHFFFAOYSA-N
Isomeric SMILESCOC1=NC=CN=C1CC(C)C
Average Molecular Weight166.2203
Monoisotopic Molecular Weight166.11061308
Classification
Description Belongs to the class of organic compounds known as methoxypyrazines. These are pyrazines containing a methoxyl group attached to the pyrazine ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDiazines
Sub ClassPyrazines
Direct ParentMethoxypyrazines
Alternative Parents
Substituents
  • Methoxypyrazine
  • Alkyl aryl ether
  • Heteroaromatic compound
  • Azacycle
  • Ether
  • Organic nitrogen compound
  • Organic oxygen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionC 65.03%; H 8.49%; N 16.85%; O 9.63%DFC
Melting PointNot Available
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
EI-MSMass Spectrum (Electron Ionization)splash10-00di-9800000000-0379fe3fc6cfe11798f3Spectrum
Predicted GC-MS2-Methoxy-3-(2-methylpropyl)pyrazine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-006x-9800000000-b2a76f846c9e6cdec480Spectrum
Predicted GC-MS2-Methoxy-3-(2-methylpropyl)pyrazine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MS2-Methoxy-3-(2-methylpropyl)pyrazine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014i-0900000000-36e5a9d0812fa5b880dcSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-014i-1900000000-a3ae70c6cad1c5005bd3Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0006-9000000000-1252189c65cc284d2024Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-014i-0900000000-f195deae40b120d03a2bSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0aor-7900000000-ce68c6d37c62fbafe643Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a59-9100000000-fdcbed3bfb97241ae911Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-014i-0900000000-f72a38590d903075c866Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-001i-2900000000-8a6a0e5c0c27143a34f1Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a4i-9300000000-02b43dab5d60f685355eSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014i-0900000000-d120bc32d136e668f60aSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-014i-2900000000-b41ddec9414daee33f17Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-014l-9100000000-4674a4a6a16f025751abSpectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
ChemSpider ID30208
ChEMBL IDCHEMBL97355
KEGG Compound IDNot Available
Pubchem Compound ID32594
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer IDNot Available
DrugBank IDDB04512
HMDB IDHMDB31860
CRC / DFC (Dictionary of Food Compounds) IDDNB60-O:DNB60-O
EAFUS ID1874
Dr. Duke ID3-ISOBUTYL-2-METHOXYPYRAZINE|2-METHOXY-3-ISOBUTYL-PYRAZINE
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDPRZ
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet ID24683-00-9
GoodScent IDrw1013601
SuperScent ID32594
Wikipedia IDNot Available
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
Flavours
FlavorCitations
earth
  1. Arn, H, Acree TE. “Flavornet: A database of aroma compounds based on odor potency in natural products”. Developments in Food Science 40 (1998): 27. doi:10.1016/S0167-4501(98)80029-0
spice
  1. Arn, H, Acree TE. “Flavornet: A database of aroma compounds based on odor potency in natural products”. Developments in Food Science 40 (1998): 27. doi:10.1016/S0167-4501(98)80029-0
green pepper
  1. Arn, H, Acree TE. “Flavornet: A database of aroma compounds based on odor potency in natural products”. Developments in Food Science 40 (1998): 27. doi:10.1016/S0167-4501(98)80029-0
pepper
  1. Dunkel, M. et al. SuperScent – a database of flavors and scents. Nucleic Acids Research 2008, doi:10.1093/nar/gkn695
  2. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
green
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
bell
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
pea
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
galbanum
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
greenpepper
  1. Arn, H, Acree TE. “Flavornet: A database of aroma compounds based on odor potency in natural products”. Developments in Food Science 40 (1998): 27. doi:10.1016/S0167-4501(98)80029-0
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).