Record Information
Version1.0
Creation date2010-04-08 22:08:24 UTC
Update date2019-11-26 03:03:24 UTC
Primary IDFDB009067
Secondary Accession Numbers
  • FDB029685
Chemical Information
FooDB NameD-Camphor
Description(+)-camphor, also known as formosa camphor or 2-bornanone, is a member of the class of compounds known as bicyclic monoterpenoids. Bicyclic monoterpenoids are monoterpenoids containing exactly 2 rings, which are fused to each other. Thus, (+)-camphor is considered to be an isoprenoid lipid molecule (+)-camphor is practically insoluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). (+)-camphor is a bitter, camphor, and herbal tasting compound and can be found in a number of food items such as sugar apple, sunflower, fennel, and cardamom, which makes (+)-camphor a potential biomarker for the consumption of these food products.
CAS Number464-49-3
Structure
Thumb
Synonyms
SynonymSource
2-BornanoneChEBI
2-CamphanoneChEBI
2-Keto-1,7,7-trimethylnorcamphaneChEBI
Formosa camphorChEBI
Gum camphorChEBI
Japan camphorChEBI
KampferChEBI
Laurel camphorChEBI
Root bark oilChEBI
Spirit OF camphorChEBI
DL-CamphorKegg
Camphor, (1R)-isomerMeSH
Camphor, (+-)-isomerMeSH
Camphor, (1S)-isomerMeSH
CamphorKEGG
-camphorbiospider
(+)-2-Bornanonebiospider
(+)-bornan-2-onebiospider
(+)-camphorbiospider
(+/-)-camphorbiospider
(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-onebiospider
(1R)-(+)-Camphorbiospider
(1R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-onebiospider
(r)-(+)-camphorbiospider
(r)-camphorbiospider
1,7,7-trimethyl-bicyclo-[2,2,1]heptane-2-onebiospider
1,7,7-trimethylbicyclo[2.2.1]-2-heptanone (camphor)biospider
1,7,7-Trimethylbicyclo[2.2.1]heptan-2-onebiospider
Alcanforbiospider
bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-biospider
Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R)-biospider
CAMbiospider
Camphor uspbiospider
Camphor, (+)-biospider
CAMPHOR, (1R,4R)-(+)-biospider
Camphor(d)biospider
D-(+)-camphorbiospider
d-2-Bornanonebiospider
d-2-Camphanonebiospider
Japanese camphorbiospider
Predicted Properties
PropertyValueSource
Water Solubility0.88 g/LALOGPS
logP2.85ALOGPS
logP2.55ChemAxon
logS-2.2ALOGPS
pKa (Strongest Basic)-7.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area17.07 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity44.49 m³·mol⁻¹ChemAxon
Polarizability17.73 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC10H16O
IUPAC name1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
InChI IdentifierInChI=1S/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3
InChI KeyDSSYKIVIOFKYAU-UHFFFAOYSA-N
Isomeric SMILESCC1(C)C2CCC1(C)C(=O)C2
Average Molecular Weight152.2334
Monoisotopic Molecular Weight152.120115134
Classification
Description Belongs to the class of organic compounds known as bicyclic monoterpenoids. These are monoterpenoids containing exactly 2 rings, which are fused to each other.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassPrenol lipids
Sub ClassMonoterpenoids
Direct ParentBicyclic monoterpenoids
Alternative Parents
Substituents
  • Bicyclic monoterpenoid
  • Bornane monoterpenoid
  • Ketone
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Ontology
OntologyNo ontology term
Physico-Chemical Properties
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionNot Available
Melting Point178.8 oC
Boiling PointNot Available
Experimental Water Solubility0.1 mg/mL at 25 oCRIDDICK,JA et al. (1986)
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MSNot Available
MS/MS
TypeDescriptionSplash KeyView
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0udi-0900000000-4cafcac5e85025eeaec82016-06-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0udi-0900000000-17669f71449bccac9c8d2016-06-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-014r-6900000000-c20f4b32cffb282dfffc2016-06-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0udi-0900000000-870908e69f6481ec31c42016-08-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0udi-0900000000-1949b2aa08f3b1e304ac2016-08-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-059f-4900000000-44e9c7b01eae3def86c42016-08-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0a4i-2900000000-2cd9a6a2424beb982a182021-10-21View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0006-9400000000-4ee1adf4cbd54fc7cd692021-10-21View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0006-9000000000-384dbbf2dde45bc0a2a42021-10-21View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0udi-0900000000-c373c9eea3cebf186f532021-10-21View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0udi-0900000000-c373c9eea3cebf186f532021-10-21View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0uea-0900000000-b2916f33f5615842d1b42021-10-21View Spectrum
NMRNot Available
ChemSpider IDNot Available
ChEMBL IDNot Available
KEGG Compound IDC00808
Pubchem Compound ID159055
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer IDNot Available
DrugBank IDDB01744
HMDB IDNot Available
CRC / DFC (Dictionary of Food Compounds) IDNot Available
EAFUS ID493
Dr. Duke IDD-CAMPHOR|CAMPHOR
BIGG IDNot Available
KNApSAcK IDC00000819
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDrw1030211
SuperScent ID159055
Wikipedia IDNot Available
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / Bioactivities
DescriptorIDDefinitionReference
AllelopathicBiochemicals that inhibit growth, survival, or reproduction in other organisms, with potential therapeutic applications in weed control, antimicrobial, and anticancer treatments, and key medical uses in developing novel pesticides, antibiotics, and chemotherapeutics.DUKE
Analgesic35480 An agent that relieves pain by reducing or blocking pain signals in the brain, commonly used to manage acute or chronic pain, inflammation, and fever, with therapeutic applications in surgery, injury, and disease treatment.DUKE
AnestheticA drug that induces a reversible loss of sensation, used to prevent pain and discomfort during medical procedures, surgeries, and diagnostic tests, promoting patient comfort and facilitating treatment.DUKE
Anti-acne50177 An agent that reduces acne symptoms, commonly used in managing acne vulgaris by minimizing oil production, preventing clogged pores, and decreasing bacterial growth, thereby reducing inflammation and promoting healthy skin.DUKE
Anti-diarrheic55323 An agent that reduces the frequency and severity of diarrhea, commonly used to manage gastrointestinal disorders, such as irritable bowel syndrome, and to treat infectious diarrhea, by slowing bowel movements and increasing water absorption.DUKE
Anti dysenteric52217 An agent that treats and prevents dysentery, reducing inflammation and diarrhea. It is used to manage bacterial, viral, or parasitic infections, and is commonly applied in treating gastrointestinal disorders, such as amoebic dysentery, and other intestinal infections.DUKE
Anti emetic50919 An agent that prevents or alleviates nausea and vomiting, playing a crucial role in managing chemotherapy-induced, motion-induced, and post-operative nausea. Therapeutically, it helps reduce discomfort and prevent dehydration, commonly used in oncology, gastroenterology, and anesthesia.DUKE
Anti feedantA substance that inhibits normal feeding behavior, found in certain plants, deterring insects and animals from consuming them. Its therapeutic applications include pest control, while key medical uses involve managing insect-borne diseases and reducing crop damage.DUKE
Anti-fibrositicAn agent that relieves inflammation and degeneration of connective tissue, particularly in joints, reducing fibrosis and promoting tissue repair, commonly used to treat conditions like arthritis and fibrotic diseases.DUKE
Anti neuralgic52217 An agent that relieves nerve pain, reducing inflammation and discomfort. It plays a biological role in blocking pain pathways, and has therapeutic applications in managing conditions like trigeminal neuralgia, shingles, and diabetic neuropathy. Key medical uses include treating severe nerve pain, numbness, and tingling sensations.DUKE
Anti pruritic50177 An agent that relieves itching sensations, reducing scratching and discomfort. It plays a biological role in inhibiting histamine release and nerve signal transmission. Therapeutically, it's used to manage itching associated with allergies, eczema, and skin irritations, providing relief and preventing further skin damage.DUKE
Anti septic33281 An agent that prevents or reduces the growth of microorganisms, such as bacteria, fungi, or viruses, to promote wound healing and prevent infection. Therapeutically, anti septics are used to treat minor cuts, scrapes, and burns, and are commonly applied topically to reduce the risk of infection and promote tissue repair. Key medical uses include wound care, surgical site preparation, and skin infection management.DUKE
Anti-spasmodic52217 An agent that relaxes smooth muscle, reducing muscle spasms and cramps. It plays a biological role in regulating muscle tone and is therapeutically applied to treat conditions such as irritable bowel syndrome, menstrual cramps, and muscle spasms, providing relief from abdominal pain and discomfort.DUKE
Cancer preventive35610 An agent that inhibits the development and progression of cancer, reducing tumor formation and growth. It plays a biological role in blocking carcinogenic pathways, and has therapeutic applications in chemoprevention. Key medical uses include reducing the risk of cancer in high-risk individuals and preventing cancer recurrence.DUKE
CarminativeAn agent that prevents or relieves gas in the gastrointestinal tract, facilitating its expulsion and combating flatulence, commonly used to soothe digestive issues and alleviate symptoms of bloating and discomfort.DUKE
Central nervous system stimulant35470 An agent that increases alertness and activity by enhancing neurotransmitter release, used therapeutically to manage attention deficit hyperactivity disorder (ADHD), narcolepsy, and fatigue, and to improve cognitive function and mood.DUKE
ConvulsantAn agent that induces convulsions and/or epileptic seizures, acting as a stimulant at low doses. It has no therapeutic applications due to its high risk of causing seizures and excitotoxicity, and is the opposite of an anticonvulsant.DUKE
Cosmetic64857 A substance used to enhance physical appearance, with no therapeutic effect. It plays a social and psychological role, boosting self-esteem and confidence. Key uses include skincare, haircare, and makeup, with no direct medical applications, but can have indirect benefits such as improving mental well-being.DUKE
CounterirritantAn agent that induces mild irritation or inflammation in one area to reduce discomfort and/or inflammation in another, often used to relieve pain, reduce swelling, and promote healing in conditions like arthritis, sprains, and strains.DUKE
Decongestant77715 An agent that reduces nasal congestion by constricting blood vessels, decreasing swelling in the nasal passages. Therapeutically, it relieves sinus pressure and eases breathing, commonly used to treat colds, allergies, and sinusitis.DUKE
DeliriantA class of hallucinogen that induces solid hallucinations, seamlessly integrating into waking consciousness. It has no established therapeutic applications, but is sometimes used in research to study psychosis and altered states of consciousness. Medical uses are limited due to its potent hallucinogenic effects.DUKE
EcbolicAn agent that induces uterine contractions, facilitating expulsion of a fetus. Its biological role is in childbirth and abortion. Therapeutically, it's used to induce labor, manage postpartum hemorrhage, and terminate pregnancies. Key medical uses include labor induction, abortion, and treating postpartum bleeding.DUKE
EmeticAn agent that induces vomiting, playing a biological role in expelling toxins from the body. Therapeutically, it is used to treat poisoning, overdose, or gastrointestinal obstruction. Key medical uses include managing drug toxicity and aiding in stomach pumping procedures.DUKE
EpileptigenicAn agent that induces or exacerbates epileptic seizures, playing a role in neurological disorders. Therapeutically, it is used to model and study epilepsy in research. Medically, understanding epileptigenic agents helps in developing treatments for epilepsy and seizure management.DUKE
Expectorant52217 An agent that thins and loosens mucus, making it easier to cough up, reducing congestion. It aids in clearing respiratory tract secretions, commonly used to relieve coughs, colds, and bronchitis, promoting easier breathing and soothing irritated airways.DUKE
Fungicide24127 An agent that kills or inhibits the growth of fungi, playing a biological role in preventing fungal infections. Therapeutically, it is used to treat fungal diseases, with key medical applications including athlete's foot, ringworm, and candidiasis, as well as agricultural uses to protect crops from fungal damage.DUKE
Herbicide24527 A chemical agent that kills or inhibits plant growth, used in agriculture to control weeds and pests. It has no direct biological role or therapeutic applications in human medicine, but its development has led to the creation of related compounds with potential medical uses, such as anticancer agents.DUKE
Insect repellent24852 An agent that deters insects, preventing bites and reducing the transmission of insect-borne diseases. Therapeutically, it helps prevent allergic reactions and decreases the risk of diseases like malaria, Zika, and Lyme disease, making it a key tool in public health and outdoor protection.DUKE
Insectifuge24852 A substance that repels insects, playing a biological role in plant defense. Therapeutically, it has applications in preventing insect-borne diseases. Key medical uses include topical repellents for malaria, dengue fever, and other vector-borne illnesses, reducing the risk of transmission.DUKE
IrritantAn agent that causes slight inflammation or discomfort, stimulating a biological response. Therapeutically, it can be used to increase blood flow or stimulate healing. Key medical uses include treating wounds, skin conditions, and respiratory issues, such as congestion, by inducing a mild inflammatory response to promote recovery.DUKE
Nematicide25491 An agent that kills nematodes, a type of parasitic worm, used to control infestations in crops and animals, with therapeutic applications in veterinary medicine to treat parasitic infections and promote livestock health.DUKE
OculoirritantAn agent that causes irritation of the eye, stimulating tear production and protective reflexes. Its biological role involves triggering a defensive response to foreign substances. Therapeutically, it has applications in ophthalmic testing and diagnostics. Key medical uses include assessing corneal health and testing tear function, helping diagnose conditions like dry eye syndrome.DUKE
Cytochrome-P450-2B1 inhibitor50183 An agent that blocks the activity of cytochrome-P450-2B1, an enzyme involved in drug metabolism. Therapeutically, it reduces toxicity and enhances efficacy of certain medications, commonly used in managing cancer, neurological disorders, and drug interactions.DUKE
Pesticide25944 An agent that kills or repels pests, playing a biological role in controlling insect, weed, and fungal populations. Therapeutically, pesticides have limited applications, but some are used to treat ectoparasitic infestations, such as lice and scabies. Key medical uses include topical treatments for head lice and scabies, highlighting their role in managing parasitic infections.DUKE
Respira inhibitor35222 An agent that blocks excessive respiratory drive, reducing breathing rate. Therapeutically, it's used to manage respiratory distress, alleviate symptoms of chronic obstructive pulmonary disease (COPD), and facilitate mechanical ventilation in critically ill patients.DUKE
RespirastimulantAn agent that stimulates an increase in tidal volume and respiratory rate, playing a biological role in enhancing respiratory function. Therapeutically, it is used to manage respiratory disorders, with key medical applications including treatment of chronic obstructive pulmonary disease (COPD), respiratory failure, and apnea.DUKE
RubefacientA topical agent that causes skin redness by dilating capillaries and increasing blood circulation, used therapeutically to relieve pain, reduce inflammation, and promote healing in conditions such as arthritis and muscle strain.DUKE
StimulantAn agent that enhances alertness, wakefulness, and physical activity by increasing brain activity. Therapeutically, it is used to treat attention deficit hyperactivity disorder (ADHD), narcolepsy, and certain cases of depression, improving focus, attention, and overall mental performance.DUKE
TransdermalA route of administration where active ingredients are delivered through the skin for systemic distribution, used therapeutically to manage conditions like pain, hormone replacement, and smoking cessation, with key medical applications including patches and implants for controlled release of medications.DUKE
VerrucolyticAn agent that treats verruca, a contagious foot wart, by breaking down the lesion, promoting healing, and reducing pain. Therapeutically, it's used to manage plantar warts, with key medical applications in podiatry and dermatology.DUKE
VibriocideAn agent destructive to Vibrio bacteria, particularly V. cholerae, used to combat cholera and other Vibrio-mediated infections, serving as a therapeutic agent in managing diarrheal diseases and preventing waterborne illnesses.DUKE
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
Flavours
FlavorCitations
medicinal
  1. Dunkel, M. et al. SuperScent – a database of flavors and scents. Nucleic Acids Research 2008, doi:10.1093/nar/gkn695
camphor
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
minty
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
phenolic
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
herbal
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
woody
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
bitter
  1. Ayana Wiener, Marina Shudler, Anat Levit, Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419. DOI:10.1093/nar/gkr755
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).
— Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.