| Synonyms | | Synonym | Source |
|---|
| 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane | ChEBI | | 2,3-Bis(3,4-dihydroxyphenylmethyl)butane | ChEBI | | 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol) | ChEBI | | 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol | ChEBI | | beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane | ChEBI | | NDGA | ChEBI | | Norhydroguaiaretic acid | ChEBI | | NSC 4291 | ChEBI | | b,g-Dimethyl-a,delta-bis(3,4-dihydroxyphenyl)butane | Generator | | Β,γ-dimethyl-α,δ-bis(3,4-dihydroxyphenyl)butane | Generator | | Norhydroguaiaretate | Generator | | b,g-Dimethyl-a,δ-bis(3,4-dihydroxyphenyl)butane | Generator | | (R*,s*)-4,4'-(2,3-dimethylbutane-1,4-diyl)bispyrocatechol | MeSH | | 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethyl-butane | HMDB | | 2,3-Bis(3,4-dihydroxybenzyl)butane | db_source | | 4, 4'-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol) | HMDB | | 4,4'- (2,3-Diemthyltetramethylene)-dipyrocatechol | HMDB | | 4,4'-(2, 3-Dimethyltetramethylene)dipyrocatechol | HMDB | | 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis-1, 2-benzenediol | HMDB | | Bisdemethyldihyroguaiaretic acid | db_source | | dihydro-Dinorguaiaretic acid | HMDB | | dihydro-Norguaiaretic acid | HMDB | | Dihydronorguaiaretic acid | HMDB | | Nordihydroguaiaretic acid | db_source | | Nordihydroguairaretic acid | HMDB |
|
|---|
| Health Effects / Bioactivities | | Descriptor | ID | Definition | Reference |
|---|
| 12-lipoxygenase inhibitor | 23924 | An agent that blocks the activity of 12-lipoxygenase, an enzyme involved in inflammation and oxidative stress. It has therapeutic applications in reducing inflammation and is used to treat conditions such as cancer, atherosclerosis, and neurodegenerative diseases. | DUKE | | 5-lipoxygenase inhibitor | 23924 | An agent that blocks the activity of 5-lipoxygenase, an enzyme involved in leukotriene production, reducing inflammation and allergic responses. Therapeutically, it's used to treat asthma, allergies, and inflammatory disorders, such as arthritis, by inhibiting the synthesis of pro-inflammatory leukotrienes. | DUKE | | Allelopathic | | Biochemicals that inhibit growth, survival, or reproduction in other organisms, with potential therapeutic applications in weed control, antimicrobial, and anticancer treatments, and key medical uses in developing novel pesticides, antibiotics, and chemotherapeutics. | DUKE | | Allergenic | 50904 | A substance that triggers an immune response, causing allergic reactions. Its biological role is to stimulate the immune system, but it has no therapeutic applications. Key medical uses include diagnosing allergies and developing immunotherapies to desensitize patients to specific allergens, reducing the risk of severe reactions. | DUKE | | Analgesic | 35480 | An agent that relieves pain by reducing or blocking pain signals in the brain, commonly used to manage acute or chronic pain, inflammation, and fever, with therapeutic applications in surgery, injury, and disease treatment. | DUKE | | Anti-aggregant | | An agent that prevents platelet aggregation, reducing blood clot formation. Its biological role is to inhibit platelet activation, and its therapeutic applications include preventing thrombosis and stroke. Key medical uses include treating cardiovascular diseases, such as myocardial infarction and atrial fibrillation, and managing conditions that increase the risk of blood clots. | DUKE | | Anti bacterial | 33282 | An agent that inhibits the growth of or destroys bacteria, playing a crucial role in preventing and treating infections. Therapeutically, it is used to combat bacterial infections, with key medical applications including treating pneumonia, tuberculosis, and skin infections, as well as preventing surgical site infections and sepsis. | DUKE | | Anti carcinogenic | 35610 | An agent that prevents or inhibits the formation of cancer, reducing tumor growth and proliferation. It plays a biological role in protecting cells from DNA damage and mutation. Therapeutically, it is used to prevent cancer development, with key medical applications in chemotherapy, radiation protection, and cancer prevention programs. | DUKE | | Anti-conjunctivitic | 52217 | An agent that reduces inflammation and prevents conjunctivitis, commonly used to treat eye infections, allergies, and irritations, promoting healthy vision and relieving symptoms such as redness, itching, and discharge. | DUKE | | Anti galactagogue | | An agent that prevents or decreases milk secretion in nursing mothers, used to suppress lactation in cases of stillbirth, abortion, or breast cancer, and to alleviate engorgement and discomfort in mothers who are not breastfeeding. | DUKE | | Anti-inflammatory | 35472 | An agent that reduces inflammation, playing a biological role in suppressing immune responses and therapeutic applications in managing pain, swelling, and redness. Key medical uses include treating arthritis, allergies, and autoimmune disorders, as well as relieving symptoms of conditions such as asthma and dermatitis. | DUKE | | Anti metabolite | | A substance that interferes with normal metabolic processes by competing with or replacing a natural metabolite, used therapeutically to treat diseases such as cancer and infections by inhibiting cell growth and proliferation. | DUKE | | Anti-mutagenic | | An agent that interferes with the mutagenicity of a substance, preventing DNA damage and mutations. Its biological role is to protect cells from genetic alterations, and it has therapeutic applications in cancer prevention and treatment, as well as key medical uses in reducing the risk of genetic disorders and birth defects. | DUKE | | Anti-oxidant | 22586 | An agent that neutralizes free radicals, reducing oxidative stress and cell damage. Its biological role involves protecting cells from harm, and it has therapeutic applications in managing chronic diseases, such as cancer, diabetes, and neurodegenerative disorders, with key medical uses including anti-aging, anti-inflammatory, and cardio protective effects. | DUKE | | Anti septic | 33281 | An agent that prevents or reduces the growth of microorganisms, such as bacteria, fungi, or viruses, to promote wound healing and prevent infection. Therapeutically, anti septics are used to treat minor cuts, scrapes, and burns, and are commonly applied topically to reduce the risk of infection and promote tissue repair. Key medical uses include wound care, surgical site preparation, and skin infection management. | DUKE | | Anti-thyroid | | An agent that inhibits thyroid hormone production, used to treat hyperthyroidism by reducing thyroid hormone levels, commonly applied in managing conditions like Graves' disease. | DUKE | | Antitumor | 35610 | An agent that inhibits tumor growth and proliferation, playing a crucial role in cancer treatment. Therapeutically, antitumors are used to manage various types of cancer, including chemotherapy, targeted therapy, and immunotherapy, helping to reduce tumor size, prevent metastasis, and improve patient outcomes. | DUKE | | Anti ulcer | 49201 | An agent that reduces stomach acid and protects the mucous lining, preventing ulcer formation. It is used to treat conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome, promoting healing and relieving symptoms. | DUKE | | Calcium antagonist | 48706 | A medication that blocks calcium ion entry into cells, reducing muscle contraction and vascular resistance. It treats hypertension, angina, and arrhythmias by dilating blood vessels and decreasing cardiac workload, commonly used in managing cardiovascular diseases. | DUKE | | Carcinogenic | 50903 | An agent that causes cancer, damaging cellular DNA and disrupting normal cell growth. It has no therapeutic applications, but understanding its biological role informs cancer prevention and treatment strategies, with key medical uses in oncology research and risk assessment. | DUKE | | Cyclooxygenase inhibitor | 35544 | An agent that blocks the activity of cyclooxygenase enzymes, reducing inflammation and pain. Therapeutically, it is used to treat conditions such as arthritis, headaches, and menstrual cramps, by decreasing prostaglandin production, a key mediator of inflammation. | DUKE | | Cytotoxic | 52209 | An agent that kills or damages cells, playing a biological role in immune responses and therapeutic applications in cancer treatment. Key medical uses include chemotherapy, targeting and destroying cancer cells, and treating certain autoimmune diseases by eliminating harmful cells. | DUKE | | Fungicide | 24127 | An agent that kills or inhibits the growth of fungi, playing a biological role in preventing fungal infections. Therapeutically, it is used to treat fungal diseases, with key medical applications including athlete's foot, ringworm, and candidiasis, as well as agricultural uses to protect crops from fungal damage. | DUKE | | Herbistat | | A topical herbal preparation with antimicrobial and anti-inflammatory properties, used to treat skin ailments such as cuts, bites, and infections, promoting wound healing and reducing the risk of infection. | DUKE | | Larvicide | | An insecticide that targets the larval life stage of insects, preventing their development into adults. Its biological role is to control insect populations, and its therapeutic applications include managing mosquito-borne diseases such as malaria and dengue fever, as well as controlling pest infestations in agriculture and public health. | DUKE | | Lipoxygenase inhibitor | 35856 | An agent that blocks the activity of lipoxygenase enzymes, reducing inflammation and oxidative stress. Therapeutically, it's used to manage conditions like asthma, atherosclerosis, and cancer, by inhibiting the production of pro-inflammatory leukotrienes. Key medical uses include treating respiratory and cardiovascular diseases. | DUKE | | Lyase inhibitor | 23924 | An agent that blocks the activity of lyase enzymes, which break down biomolecules. It has therapeutic applications in reducing inflammation and oxidative stress, with key medical uses in managing cancer, cardiovascular disease, and neurodegenerative disorders. | DUKE | | NADPH-oxidase inhibitor | 50423 | An agent that blocks the activity of NADPH-oxidase, reducing oxidative stress and inflammation. Therapeutically, it's used to manage conditions like atherosclerosis, hypertension, and neurodegenerative diseases, by mitigating oxidative damage and improving cardiovascular health. | DUKE | | Pesticide | 25944 | An agent that kills or repels pests, playing a biological role in controlling insect, weed, and fungal populations. Therapeutically, pesticides have limited applications, but some are used to treat ectoparasitic infestations, such as lice and scabies. Key medical uses include topical treatments for head lice and scabies, highlighting their role in managing parasitic infections. | DUKE | | Phospholipase inhibitor | 23924 | An agent that blocks phospholipase enzymes, reducing inflammation and cell damage. Therapeutically, it's used to treat conditions like pancreatitis and sepsis, and has potential in managing neurodegenerative and cardiovascular diseases by inhibiting phospholipid breakdown and modulating immune responses. | DUKE | | Phytotoxic | | An agent poisonous to plants, inhibiting growth and development. Its biological role involves disrupting plant cell function. Therapeutically, phytotoxic agents are used as herbicides, while medically, they have applications in cancer treatment and as antimicrobial agents, targeting plant-like pathogens. | DUKE | | Respiroinhibitor | 35222 | An agent that inhibits cellular respiration, reducing energy production. Therapeutically, it is used to manage cancer, infectious diseases, and other conditions by targeting abnormal cell metabolism, with key applications in oncology and antimicrobial therapy. | DUKE |
|
|---|
