| Analgesic | 35480 | An agent that relieves pain by reducing or blocking pain signals in the brain, commonly used to manage acute or chronic pain, inflammation, and fever, with therapeutic applications in surgery, injury, and disease treatment. | DUKE |
| Anorexic | 50780 | An agent that suppresses appetite, reducing food intake. Its biological role involves regulating hunger and satiety signals. Therapeutically, anorexics are used to treat obesity and weight-related disorders, promoting weight loss and improving metabolic health. Key medical uses include managing exogenous obesity and related conditions, such as diabetes and hypertension. | DUKE |
| Anti-acne | 50177 | An agent that reduces acne symptoms, commonly used in managing acne vulgaris by minimizing oil production, preventing clogged pores, and decreasing bacterial growth, thereby reducing inflammation and promoting healthy skin. | DUKE |
| Anti-aggregant | | An agent that prevents platelet aggregation, reducing blood clot formation. Its biological role is to inhibit platelet activation, and its therapeutic applications include preventing thrombosis and stroke. Key medical uses include treating cardiovascular diseases, such as myocardial infarction and atrial fibrillation, and managing conditions that increase the risk of blood clots. | DUKE |
| Anti-angiogenic | 48422 | An agent that inhibits the formation of new blood vessels, playing a crucial role in cancer treatment by starving tumors of oxygen and nutrients. Therapeutically, it is used to manage cancer, age-related macular degeneration, and other diseases characterized by excessive angiogenesis, reducing tumor growth and slowing disease progression. | DUKE |
| Anti-arthritic | 52217 | An agent that reduces joint inflammation and alleviates symptoms of arthritis, commonly used in managing rheumatoid arthritis, osteoarthritis, and other inflammatory joint disorders, to improve mobility and quality of life. | DUKE |
| Anti-asthmatic | 49167 | An agent that relieves bronchospasm and inflammation, commonly used to manage asthma symptoms, chronic obstructive pulmonary disease (COPD), and other respiratory disorders, improving lung function and overall respiratory health. | DUKE |
| Anti-atherosclerotic | 38070 | An agent that prevents or slows the formation of atherosclerosis, a condition characterized by plaque buildup in arteries. It reduces inflammation, improves lipid profiles, and inhibits platelet aggregation, commonly used to manage cardiovascular diseases, such as coronary artery disease, and prevent heart attacks and strokes. | DUKE |
| Anti-cataract | 52217 | An agent that prevents or slows the formation of cataracts, reducing oxidative stress and inflammation in the lens of the eye, commonly used to manage age-related cataracts and other ocular disorders. | DUKE |
| Anti-cirrhotic | 52217 | An agent that prevents or treats liver cirrhosis, reducing fibrosis and promoting liver health. It inhibits liver scarring, commonly used in managing liver diseases such as hepatitis and fatty liver disease. | DUKE |
| Anti climacteric | | An agent that alleviates symptoms of male menopause, including reduced libido and sexual activity, by regulating hormonal imbalances, with therapeutic applications in managing andropause and key medical uses in treating age-related sexual dysfunction. | DUKE |
| Anti coronary | 52217 | An agent that reduces the risk of coronary artery disease, lowering blood pressure and cholesterol levels. It helps prevent heart attacks, strokes, and other cardiovascular events, commonly used in managing hypertension, hyperlipidemia, and atherosclerosis. | DUKE |
| Anti-dandruff | | An agent that reduces the production or flaking of dandruff, treating scalp conditions like seborrheic dermatitis, psoriasis, and eczema, by inhibiting fungal growth and inflammation, promoting a healthy scalp. | DUKE |
| Anti depressant | 52217 | An agent that regulates mood, reducing symptoms of depression and anxiety by altering neurotransmitter levels in the brain, commonly used in managing depression, anxiety disorders, and other mood disorders. | DUKE |
| Antidote | 50247 | An agent that counteracts a poison or toxin, neutralizing its harmful effects. It plays a biological role in reversing toxicity, and has therapeutic applications in treating poisoning, overdose, and envenomation. Key medical uses include emergency treatment for snake bites, drug overdose, and chemical exposure. | DUKE |
| Anti-fibrotic | | An agent that inhibits excessive fibrous tissue formation, reducing scarring and organ damage. Therapeutically, it's used to treat conditions like pulmonary fibrosis, liver cirrhosis, and kidney fibrosis, slowing disease progression and improving organ function. | DUKE |
| Anti-gout | 52217 | An agent that reduces uric acid levels, used to treat and prevent gout attacks, managing symptoms such as joint pain and inflammation, and commonly prescribed for hyperuricemia and chronic gout management. | DUKE |
| Anti HIV | 22587 | An agent that prevents the replication of the Human Immunodeficiency Virus (HIV), used to treat and manage HIV infection and Acquired Immunodeficiency Syndrome (AIDS), reducing viral load and slowing disease progression. | DUKE |
| Anti Keshan | | An antioxidant and selenium-containing compound, playing a biological role in protecting against oxidative stress and cell damage. Therapeutically, it is used to prevent Keshan disease, a cardiomyopathy caused by selenium deficiency. Key medical uses include treating and preventing selenium deficiency-related disorders, and supporting cardiovascular health. | DUKE |
| Anti leukemic | 35610 | An agent that targets and inhibits the growth of leukemia cells, playing a crucial role in cancer treatment. Therapeutically, it is used to induce remission, manage symptoms, and improve survival rates in patients with leukemia. Key medical uses include treating acute and chronic leukemia, lymphoma, and other hematological malignancies. | DUKE |
| Anti leukotriene | 35222 | An agent that blocks the action of leukotrienes, reducing inflammation and bronchoconstriction. Therapeutically, it is used to treat asthma, allergic rhinitis, and other respiratory disorders by inhibiting the biological role of leukotrienes in mediating inflammatory responses. | DUKE |
| Anti-maculitic | | An agent that reduces macular inflammation, commonly used in managing age-related macular degeneration and diabetic macular edema, promoting vision preservation and reducing disease progression. | DUKE |
| Anti-melanomic | 35610 | An agent that inhibits melanin production, reducing melanoma cell growth. It has therapeutic applications in treating skin cancers, particularly melanoma, and key medical uses include preventing tumor progression and metastasis, as well as managing pigmentation disorders. | DUKE |
| Anti-menopausal | 52217 | An agent that alleviates menopausal symptoms, regulating hormonal balance and reducing discomfort. Therapeutically, it is used to manage hot flashes, night sweats, and mood changes, improving quality of life for menopausal women. Key medical uses include hormone replacement therapy and treatment of menopause-related disorders. | DUKE |
| Anti metastatic | 35610 | An agent that inhibits cancer cell spread, reducing tumor metastasis. It plays a biological role in blocking cell migration and invasion, and has therapeutic applications in cancer treatment. Key medical uses include preventing cancer recurrence and improving survival rates in patients with various types of cancer. | DUKE |
| Anti-myalgic | | An agent that relieves muscle pain or tenderness, playing a biological role in reducing inflammation and muscle spasms. Therapeutically, it's used to manage muscle disorders, with key medical applications in treating fibromyalgia, arthritis, and muscle injuries, providing pain relief and improving mobility. | DUKE |
| Anti NF-kappa-B | 35222 | An agent that inhibits the activity of NF-kappa-B, a protein complex involved in inflammation and immune responses. It reduces inflammation and has therapeutic applications in managing autoimmune diseases, cancer, and inflammatory disorders, with key medical uses including treatment of rheumatoid arthritis, asthma, and certain types of cancer. | DUKE |
| Anti osteoarthritic | 52217 | An agent that reduces inflammation and slows cartilage degradation, commonly used to manage osteoarthritis symptoms, promoting joint health and relieving pain. | DUKE |
| Anti-oxidant | 22586 | An agent that neutralizes free radicals, reducing oxidative stress and cell damage. Its biological role involves protecting cells from harm, and it has therapeutic applications in managing chronic diseases, such as cancer, diabetes, and neurodegenerative disorders, with key medical uses including anti-aging, anti-inflammatory, and cardio protective effects. | DUKE |
| Anti-Parkinsonian | 48407 | An agent that alleviates symptoms of Parkinson's disease, enhancing dopamine levels and improving motor function, commonly used to manage tremors, rigidity, and bradykinesia in neurodegenerative disorders. | DUKE |
| Anti proliferant | | An agent that prevents or inhibits cell growth and division, used therapeutically to treat cancer, manage tumor growth, and prevent restenosis after angioplasty, reducing abnormal cell proliferation. | DUKE |
| Anti radicular | | An agent that relieves inflammation or irritation of the nerve root of a tooth, reducing pain and discomfort. Its biological role is to target and alleviate radicular pain, with therapeutic applications in endodontics and key medical uses in root canal treatments and tooth sensitivity management. | DUKE |
| Anti-rheumatic | 52217 | An agent that reduces inflammation and alleviates symptoms of rheumatic diseases, such as arthritis. It plays a biological role in modulating the immune system and inhibiting pro-inflammatory pathways. Therapeutically, anti-rheumatics are used to manage conditions like rheumatoid arthritis, lupus, and osteoarthritis, reducing pain, swelling, and joint damage. Key medical uses include slowing disease progression and improving quality of life for patients with chronic rheumatic conditions. | DUKE |
| Anti syndrome-X | 52217 | An agent that improves insulin sensitivity, reducing glucose and lipid levels. It plays a biological role in regulating metabolic pathways, and has therapeutic applications in managing insulin resistance, type 2 diabetes, and cardiovascular disease, making it a key medical use in preventing and treating metabolic syndrome. | DUKE |
| Antitumor | 35610 | An agent that inhibits tumor growth and proliferation, playing a crucial role in cancer treatment. Therapeutically, antitumors are used to manage various types of cancer, including chemotherapy, targeted therapy, and immunotherapy, helping to reduce tumor size, prevent metastasis, and improve patient outcomes. | DUKE |
| Anti-ulcerogenic | 49201 | An agent that prevents or reduces the formation of ulcers, particularly in the stomach and intestines. It plays a biological role in protecting the mucosal lining, and has therapeutic applications in managing gastroesophageal reflux disease (GERD), peptic ulcers, and other gastrointestinal disorders. | DUKE |
| Anxiolytic | 35474 | An agent that reduces anxiety symptoms, commonly used in managing anxiety disorders, such as generalized anxiety disorder and panic disorder, by modulating neurotransmitters like GABA, promoting relaxation and calming effects. | DUKE |
| Activator-protein-1 inhibitor | 35222 | An agent that blocks the activity of activator protein-1 (AP-1), a transcription factor involved in inflammation and cell growth. It has therapeutic applications in reducing inflammation, cancer progression, and fibrosis, with key medical uses in treating conditions such as arthritis, cancer, and skin disorders. | DUKE |
| Apoptotic | | An agent that stimulates programmed cell death, playing a crucial biological role in eliminating damaged or unwanted cells. It has therapeutic applications in cancer treatment, and key medical uses include inducing cell death in malignant cells, reducing tumor growth, and enhancing chemotherapy efficacy. | DUKE |
| Cancer preventive | 35610 | An agent that inhibits the development and progression of cancer, reducing tumor formation and growth. It plays a biological role in blocking carcinogenic pathways, and has therapeutic applications in chemoprevention. Key medical uses include reducing the risk of cancer in high-risk individuals and preventing cancer recurrence. | DUKE |
| Cardioprotective | 38070 | An agent that protects the heart from damage, reducing the risk of cardiovascular disease. It plays a biological role in mitigating cardiac stress and injury, with therapeutic applications in preventing heart attacks, strokes, and arrhythmias, and key medical uses in treating hypertension, heart failure, and coronary artery disease. | DUKE |
| Depressant | | An agent that lowers neurotransmission levels, reducing arousal or stimulation in the brain, used therapeutically to treat anxiety, insomnia, and seizures, and medically to induce sedation and relieve symptoms of certain conditions. | DUKE |
| Fungicide | 24127 | An agent that kills or inhibits the growth of fungi, playing a biological role in preventing fungal infections. Therapeutically, it is used to treat fungal diseases, with key medical applications including athlete's foot, ringworm, and candidiasis, as well as agricultural uses to protect crops from fungal damage. | DUKE |
| Immunomodulator | 50846 | An agent that regulates the immune system, modifying its response to maintain balance. Therapeutically, it's used to treat autoimmune diseases, prevent transplant rejection, and manage chronic inflammatory conditions, such as rheumatoid arthritis and multiple sclerosis. | DUKE |
| Immunostimulant | 50847 | An agent that stimulates the immune system, enhancing its response to infections and diseases. Therapeutically, it boosts the body's natural defenses, commonly used to treat immunodeficiency disorders, prevent infections, and support cancer treatment, as well as manage chronic conditions like hepatitis and HIV. | DUKE |
| NF-kappa-B inhibitor | 35222 | An agent that blocks the activity of NF-kappa-B, a protein complex involved in inflammation and immune responses, reducing inflammation and cell proliferation. Therapeutically, it is used to treat conditions such as cancer, autoimmune disorders, and inflammatory diseases, including rheumatoid arthritis and asthma. | DUKE |
| Ornithine-decarboxylase inhibitor | 23924 | An agent that blocks the activity of ornithine decarboxylase, an enzyme involved in cell growth and proliferation. It reduces polyamine synthesis, inhibiting tumor growth and proliferation. Therapeutically, it is used to treat cancer, particularly in combination with other therapies, and has potential applications in managing parasitic infections and skin disorders. | DUKE |
| Pesticide | 25944 | An agent that kills or repels pests, playing a biological role in controlling insect, weed, and fungal populations. Therapeutically, pesticides have limited applications, but some are used to treat ectoparasitic infestations, such as lice and scabies. Key medical uses include topical treatments for head lice and scabies, highlighting their role in managing parasitic infections. | DUKE |
| Protein kinase C inhibitor | 37700 | An agent that blocks protein kinase C activity, reducing cell signaling and inflammation. Therapeutically, it's used to treat cancer, cardiovascular diseases, and neurological disorders, with key medical applications in managing Alzheimer's disease, diabetes, and stroke. | DUKE |
| Polyamine synthesis inhibitor | 35222 | An agent that blocks the production of polyamines, essential for cell growth and proliferation, reducing cancer cell growth and tumor formation, with therapeutic applications in oncology, particularly in treating various types of cancer. | DUKE |
| Prostaglandin sparer | | An agent that conserves prostaglandins, reducing their breakdown and promoting their beneficial effects, such as protecting the gastrointestinal mucosa. Therapeutically, it is used to prevent NSAID-induced ulcers and gastritis, and has key medical applications in managing gastroesophageal reflux disease and inflammatory bowel disease. | DUKE |
| VEGF inhibitor | 35222 | An agent that blocks the activity of Vascular Endothelial Growth Factor (VEGF), reducing angiogenesis. Therapeutically, it's used to treat cancer, age-related macular degeneration, and diabetic retinopathy by inhibiting tumor growth and abnormal blood vessel formation. | DUKE |
