Record Information
Version1.0
Creation date2010-04-08 22:11:18 UTC
Update date2019-11-26 03:10:13 UTC
Primary IDFDB014504
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameFolic acid
DescriptionFolic acid, also known as folate or folsaeure, belongs to the class of organic compounds known as methoxyphenols. Methoxyphenols are compounds containing a methoxy group attached to the benzene ring of a phenol moiety. Folic acid is a moderately basic compound (based on its pKa). Folic acid exists in all living species, ranging from bacteria to humans. Folic acid is a potentially toxic compound. Folic acid, with regard to humans, has been found to be associated with several diseases such as fibromyalgia, hereditary folate malabsorption, bladder infections, and alzheimer's disease; folic acid has also been linked to the inborn metabolic disorder folate deficiency.
CAS Number59-30-3
Structure
Thumb
Synonyms
SynonymSource
FolateChEBI
FolsaeureChEBI
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acidChEBI
N-Pteroyl-L-glutamic acidChEBI
PGAChEBI
PteGluChEBI
Pteroyl-L-glutamic acidChEBI
Pteroyl-L-monoglutamic acidChEBI
Pteroylglutamic acidChEBI
Vitamin BCChEBI
Vitamin mChEBI
FolicetKegg
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamateGenerator
N-Pteroyl-L-glutamateGenerator
Pteroyl-L-glutamateGenerator
Pteroyl-L-monoglutamateGenerator
PteroylglutamateGenerator
AcifolicHMDB
CytofolHMDB
Dosfolat b activHMDB
FolacidHMDB
FolacinHMDB
FolbalHMDB
FolcidinHMDB
FoldineHMDB
FolettesHMDB
FoliaminHMDB
FolipacHMDB
FolsanHMDB
FolsaureHMDB
FolsavHMDB
FolviteHMDB
IncafolicHMDB
Liver lactobacillus casei factorHMDB
MillafolHMDB
N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acidHMDB
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acidHMDB
Pteroylmonoglutamic acidHMDB
Vitamin beHMDB
Folic acid, (DL)-isomerHMDB
Folic acid, sodium saltHMDB
Folic acid, (D)-isomerHMDB
Folic acid, monosodium saltHMDB
Folic acid, potassium saltHMDB
b9, VitaminHMDB
Folic acid, calcium salt (1:1)HMDB
Folic acid, monopotassium saltHMDB
Vitamin b9HMDB
Citrovorindb_source
Coenzyme Fdb_source
Factor ubiospider
Folcysteinebiospider
Folic acidbiospider
Foluitebiospider
Folvronbiospider
Leucaldb_source
Mittafolbiospider
N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]glutamic acid, 9CIdb_source
N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-Pteridinyl)methyl]amino]benzoyl]-L-glutamic acidHMDB
Pteroylmonoglutamatebiospider
Vitamin bbiospider
Vitamin B11biospider
Vitamin B9biospider
Vitamin Bcdb_source
Vitamin Mdb_source
Predicted Properties
PropertyValueSource
Water Solubility0.076 g/LALOGPS
logP-0.04ALOGPS
logP-0.68ChemAxon
logS-3.8ALOGPS
pKa (Strongest Acidic)3.37ChemAxon
pKa (Strongest Basic)2.09ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area208.99 ŲChemAxon
Rotatable Bond Count9ChemAxon
Refractivity111.01 m³·mol⁻¹ChemAxon
Polarizability42.06 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Chemical FormulaC19H19N7O6
IUPAC name(2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
InChI IdentifierInChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
InChI KeyOVBPIULPVIDEAO-LBPRGKRZSA-N
Isomeric SMILESNC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1
Average Molecular Weight441.3975
Monoisotopic Molecular Weight441.139681375
Classification
Description Belongs to the class of organic compounds known as methoxyphenols. Methoxyphenols are compounds containing a methoxy group attached to the benzene ring of a phenol moiety.
KingdomOrganic compounds
Super ClassBenzenoids
ClassPhenols
Sub ClassMethoxyphenols
Direct ParentMethoxyphenols
Alternative Parents
Substituents
  • Methoxyphenol
  • Phenoxy compound
  • Anisole
  • Methoxybenzene
  • Phenol ether
  • 1-hydroxy-2-unsubstituted benzenoid
  • Alkyl aryl ether
  • Monocyclic benzene moiety
  • Carboxylic acid derivative
  • Monocarboxylic acid or derivatives
  • Ether
  • Carboxylic acid
  • Organic oxygen compound
  • Organooxygen compound
  • Carbonyl group
  • Hydrocarbon derivative
  • Organic oxide
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Process

Naturally occurring process:

Role

Industrial application:

Biological role:

Physico-Chemical Properties
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateSolid
Physical DescriptionNot Available
Mass CompositionC 51.70%; H 4.34%; N 22.21%; O 21.75%DFC
Melting Point250 oC
Boiling PointNot Available
Experimental Water Solubility0.0016 mg/mL at 25 oCMERCK INDEX (1983)
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical Rotation[a]25D +23 (c, 0.5 in 1M NaOH)DFC
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
EI-MSMass Spectrum (Electron Ionization)splash10-0006-9410000000-7cba521e8707575394242014-09-20View Spectrum
Predicted GC-MSFolic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0002-2249100000-5ad16461f6638538ea08Spectrum
Predicted GC-MSFolic acid, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-00xr-4205390000-4152e24c68306bfe6554Spectrum
Predicted GC-MSFolic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_1_1, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_1_2, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_1_3, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_1_4, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_1_5, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_1_6, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_2, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_3, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_4, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_5, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_6, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_7, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_8, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_9, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_10, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_11, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_12, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_13, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_14, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_15, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TMS_2_16, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSFolic acid, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0006-0000900000-4208ea3c2f5d9026c19f2012-07-24View Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0006-0050900000-2c8ad037dc3b270765c42012-07-24View Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0007-0090300000-ebdec84cbb7fe5afbc0b2012-07-24View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0007-0903600000-e5d91e4f2ab79d130b762012-08-31View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-qTof , Positivesplash10-002b-0960000000-108d96993dc78f1e4b612017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-0007-0903600000-e5d91e4f2ab79d130b762017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - , positivesplash10-002b-0960000000-108d96993dc78f1e4b612017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Positivesplash10-0002-0090000000-9e9a33bc590d0f8019292021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 30V, Positivesplash10-0aba-6940000000-f0b6076af9cb594136562021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 0V, Positivesplash10-0005-0090600010-5ef6e95b870cc0ebfeb82021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 20V, Positivesplash10-0002-0190000000-2d1f624dc1d2d929527f2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 90V, Negativesplash10-015c-9700000000-5a0aeec6b1c2bfddfdf12021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Positivesplash10-0002-0090000000-b750c262ac740994e33a2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 0V, Positivesplash10-0005-0090600000-c0e3753ba3591c41d1db2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 75V, Negativesplash10-001i-3900000000-4d5187e4336ce6be5eb72021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 40V, Positivesplash10-00b9-0910000000-b3bc3e8ccbba45c85e782021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Positivesplash10-0002-0090000010-2c53d9aa251e756381832021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Negativesplash10-0006-0000900000-7370828adb963cbb92462021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 20V, Negativesplash10-0006-0000900000-3b979cd5ecd30ae0d2bf2021-09-20View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00bd-0544900000-aa9a130e2cf3dacfb9542016-09-14View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-004j-0954100000-7be7eac442233b5d3bcf2016-09-14View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-004i-1960000000-1950169762886f41b6ec2016-09-14View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0006-0114900000-bff7f5f3d20dcd6a44942016-09-14View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-00r7-1249300000-e322ba8675bb922877a92016-09-14View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0006-9652000000-8c87fa7172ed19a7eb272016-09-14View Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, experimental)Spectrum
1D NMR1H NMR Spectrum (1D, 400 MHz, DMSO-d6, experimental)Spectrum
1D NMR13C NMR Spectrum (1D, 22.53 MHz, DMSO-d6, experimental)Spectrum
1D NMR1H NMR Spectrum (1D, D2O, experimental)Spectrum
1D NMR13C NMR Spectrum (1D, D2O, experimental)Spectrum
1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)Spectrum
2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 600 MHz, H2O, experimental)Spectrum
ChemSpider ID5815
ChEMBL IDCHEMBL1622
KEGG Compound IDC00504
Pubchem Compound ID6037
Pubchem Substance IDNot Available
ChEBI ID27470
Phenol-Explorer IDNot Available
DrugBank IDDB00158
HMDB IDHMDB00121
CRC / DFC (Dictionary of Food Compounds) IDJRL93-O:JRL93-O
EAFUS ID1396
Dr. Duke IDFOLIC-ACID|FOLACIN|FOLATE
BIGG ID35180
KNApSAcK IDC00001539
HET IDFOL
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDrw1098971
SuperScent IDNot Available
Wikipedia IDFolic acid
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / Bioactivities
DescriptorIDDefinitionReference
Anti-anemic52217 An agent that treats or prevents anemia by increasing red blood cell production or enhancing iron utilization, commonly used to manage iron-deficiency anemia, vitamin deficiency anemia, and other blood disorders, promoting healthy oxygen delivery to tissues and organs.DUKE
Anti-cervicaldysplasic52217 An agent that prevents or treats cervical dysplasia, a precancerous condition. It helps maintain normal cell growth, reducing the risk of cervical cancer. Therapeutically, it is used to manage abnormal cell changes in the cervix, often caused by HPV infection, and is a key component in cervical cancer prevention and treatment strategies.DUKE
Anti cheiliticAn agent that treats cheilitis, reducing inflammation and discomfort. Examples include corticosteroids and anti-inflammatory agents, commonly used to manage cheilitis symptoms and promote healing.DUKE
Anti coronary52217 An agent that reduces the risk of coronary artery disease, lowering blood pressure and cholesterol levels. It helps prevent heart attacks, strokes, and other cardiovascular events, commonly used in managing hypertension, hyperlipidemia, and atherosclerosis.DUKE
Anti-dementia52217 An agent that slows or prevents cognitive decline, reducing symptoms of dementia. It plays a biological role in neuroprotection, enhancing neuronal function and survival. Therapeutically, it is used to manage Alzheimer's disease, vascular dementia, and other neurodegenerative disorders, improving memory, cognition, and daily functioning.DUKE
Anti depressant52217 An agent that regulates mood, reducing symptoms of depression and anxiety by altering neurotransmitter levels in the brain, commonly used in managing depression, anxiety disorders, and other mood disorders.DUKE
Anti-gingivitic52217 An agent that reduces gingivitis symptoms, commonly used in managing plaque, inflammation, and gum disease, promoting oral health by preventing bacterial growth and infection.DUKE
Anti-glossiticAn agent that relieves inflammation of the tongue, or glossitis, playing a role in reducing pain and discomfort. Therapeutically, it is used to treat tongue inflammation, often caused by nutritional deficiencies or infections. Key medical uses include managing glossitis symptoms, promoting oral health, and improving quality of life for patients with tongue inflammation.DUKE
Anti-gout52217 An agent that reduces uric acid levels, used to treat and prevent gout attacks, managing symptoms such as joint pain and inflammation, and commonly prescribed for hyperuricemia and chronic gout management.DUKE
Anti-infertility52217 An agent that enhances reproductive health, promoting fertility and conception. Its biological role involves regulating hormonal balance and improving reproductive function. Therapeutically, it is used to treat infertility disorders, with key medical applications in assisted reproduction, polycystic ovary syndrome (PCOS), and unexplained infertility.DUKE
Anti metaplasticAn antibody targeting metaplastic carcinoma of the breast, playing a role in cancer treatment. Its therapeutic application involves inhibiting tumor growth and metastasis. Key medical uses include treating metaplastic breast cancer, a rare and aggressive subtype, offering a potential therapeutic option for patients with limited treatment choices.DUKE
Anti myelotoxic50247 An agent that protects the bone marrow from damage, reducing the toxic effects of chemotherapy and radiation on blood cell production, commonly used to support cancer treatment and manage related side effects.DUKE
Anti neuropathicAn agent that relieves symptoms such as pain, numbness, and tingling caused by damage or disease affecting the somatosensory nervous system, commonly used in managing conditions like diabetes, shingles, and nerve injuries.DUKE
Anti periodontalAn agent that prevents or treats gum disease, reducing inflammation and infection in the gums and supporting tissues of the teeth, commonly used in managing periodontitis and promoting oral health.DUKE
Anti periodontiticAn agent that reduces inflammation of tissue around teeth, preventing gum shrinkage and tooth loosening, commonly used to treat periodontal disease and promote oral health.DUKE
Anti-plaqueAn agent that removes or prevents the formation of dental plaque, a biofilm of bacteria, to prevent tooth decay and gum disease, commonly used in oral care products and therapeutic applications for periodontal health.DUKE
Anti polypAn agent that removes or prevents overgrowth of the inner wall of the colon or rectum, playing a role in colon health. Therapeutically, it helps prevent colorectal polyps, reducing the risk of colorectal cancer. Key medical uses include preventing polyp recurrence and managing conditions like familial adenomatous polyposis.DUKE
Anti psychotic35476 An agent that reduces psychotic symptoms, commonly used in managing schizophrenia, bipolar disorder, and other mental health conditions by blocking dopamine receptors in the brain, thereby alleviating hallucinations, delusions, and disordered thinking.DUKE
Anti spina-bifida52217 An agent that prevents or reduces the occurrence of spina bifida, a birth defect where the spine and spinal cord don't form properly. Its biological role is to promote proper neural tube formation. Therapeutically, it's used to prevent birth defects, particularly in high-risk pregnancies. Key medical uses include prenatal care and fetal development support, often involving folic acid supplementation.DUKE
Cancer preventive35610 An agent that inhibits the development and progression of cancer, reducing tumor formation and growth. It plays a biological role in blocking carcinogenic pathways, and has therapeutic applications in chemoprevention. Key medical uses include reducing the risk of cancer in high-risk individuals and preventing cancer recurrence.DUKE
HematopoieticAn agent that stimulates the production of all types of blood cells, playing a crucial role in hematopoiesis. Therapeutically, it is used to treat blood disorders, such as anemia, and to support recovery after chemotherapy or bone marrow transplantation, promoting healthy blood cell production.DUKE
Immunostimulant50847 An agent that stimulates the immune system, enhancing its response to infections and diseases. Therapeutically, it boosts the body's natural defenses, commonly used to treat immunodeficiency disorders, prevent infections, and support cancer treatment, as well as manage chronic conditions like hepatitis and HIV.DUKE
UricosuricA substance that increases uric acid excretion in the urine, reducing blood plasma concentration. It plays a biological role in preventing uric acid buildup. Therapeutically, it's used to treat gout and hyperuricemia, managing symptoms and preventing complications. Key medical uses include reducing uric acid levels and alleviating gout attacks.DUKE
Xanthine oxidase inhibitor35634 An agent that blocks xanthine oxidase, an enzyme involved in uric acid production, reducing inflammation and oxidative stress. Therapeutically, it's used to treat gout, hyperuricemia, and prevent kidney stones, with key applications in managing cardiovascular disease and improving kidney function.DUKE
Enzymes
NameGene NameUniProt ID
Formimidoyltransferase-cyclodeaminaseFTCDO95954
Thiamine transporter 1SLC19A2O60779
Dihydrofolate reductaseDHFRP00374
Folate receptor alphaFOLR1P15328
Folate transporter 1SLC19A1P41440
Folate receptor gammaFOLR3P41439
Gamma-glutamyl hydrolaseGGHQ92820
Pathways
NameSMPDB LinkKEGG Link
Folate MetabolismSMP00053 map00670
Pterine BiosynthesisSMP00005 map00790
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
Flavours
FlavorCitations
odorless
  1. The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
Files
MSDSshow
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Saxholt, E., et al. 'Danish food composition databank, revision 7.' Department of Nutrition, National Food Institute, Technical University of Denmark (2008).
— U.S. Department of Agriculture, Agricultural Research Service. 2008. USDA National Nutrient Database for Standard Reference, Release 21. Nutrient Data Laboratory Home Page.
— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).
— Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.