1.0 2026-09-21 17:03:31 UTC 2026-09-21 17:03:31 UTC FDB116776 Palmatine 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium C21H22NO4 352.409 352.154334613 3,4,10,11-tetramethoxy-7,8-dihydro-6λ⁵-azatetraphen-6-ylium palmatine COC1=CC=C2C=C3C4=CC(OC)=C(OC)C=C4CC[N+]3=CC2=C1OC InChI=1S/C21H22NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,9-12H,7-8H2,1-4H3/q+1 QUCQEUCGKKTEBI-UHFFFAOYSA-N belongs to the class of organic compounds known as protoberberine alkaloids and derivatives. These are alkaloids with a structure based on a protoberberine moiety, which consists of a 5,6-dihydrodibenzene moiety fused to a quinolizinium and forming 5,6-Dihydrodibenzo(a,g)quinolizinium skeleton. Protoberberine alkaloids and derivatives Organic compounds Alkaloids and derivatives Protoberberine alkaloids and derivatives Aromatic heteropolycyclic compounds Alkyl aryl ethers Anisoles Azacyclic compounds Heteroaromatic compounds Hydrocarbon derivatives Isoquinolines and derivatives Organic cations Organonitrogen compounds Organopnictogen compounds Pyridinium derivatives Alkyl aryl ether Anisole Aromatic heteropolycyclic compound Azacycle Benzenoid Ether Heteroaromatic compound Hydrocarbon derivative Isoquinoline Organic cation Organic nitrogen compound Organic oxygen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Protoberberine skeleton Pyridine Pyridinium Isoquinoline alkaloids a small molecule berberine alkaloid organic heterotetracyclic compound logp 0.28 ALOGPS logs -6.55 ALOGPS solubility 1.10e-04 g/l ALOGPS logp -1.2 ChemAxon pka_strongest_basic -4.3 ChemAxon iupac 3,4,10,11-tetramethoxy-7,8-dihydro-6λ⁵-azatetraphen-6-ylium ChemAxon average_mass 352.409 ChemAxon mono_mass 352.154334613 ChemAxon smiles COC1=CC=C2C=C3C4=CC(OC)=C(OC)C=C4CC[N+]3=CC2=C1OC ChemAxon formula C21H22NO4 ChemAxon inchi InChI=1S/C21H22NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,9-12H,7-8H2,1-4H3/q+1 ChemAxon inchikey QUCQEUCGKKTEBI-UHFFFAOYSA-N ChemAxon polar_surface_area 40.8 ChemAxon refractivity 100.68 ChemAxon polarizability 39.51 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 4 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 1 ChemAxon